Increased motor cortex white matter volume predicts motor impairment in autism.
Careful consideration of motor impairments, such as those documented in autism, can afford valuable insights into the neurological basis of developmental disorders. Motor signs are highly quantifiable and reproducible and can serve as markers for deficits in parallel systems important for socializat...
| Publicado en: | Brain: A Journal of Neurology Vol. 130; no. 8; pp. 2117 - 2123 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
Aug2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105979514&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105979514 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00068950 2RY jtl: Brain: A Journal of Neurology issn: 00068950 maglogo: N pubinfo: dt: Aug2007 vid: 130 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105979514 NLM17575280 2009663763 10.1093/brain/awm129 NLM17575280 105979514 ppf: 2117 ppct: 6 formats: tig: atl: Increased motor cortex white matter volume predicts motor impairment in autism. aug: au: Mostofsky SH Burgess MP Larson JCG Mostofsky, Stewart H Burgess, Melanie P Gidley Larson, Jennifer C affil: Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205, USA sug: subj: Autism Spectrum Disorder Psychosocial Factors Frontal Lobe Pathology Motor Skills Disorders Etiology Attention Deficit Hyperactivity Disorder Psychosocial Factors Attention Deficit Hyperactivity Disorder Autism Spectrum Disorder Brain Pathology Child Female Magnetic Resonance Imaging Methods Male Motor Skills Disorders Prognosis Severity of Illness Indices Human Child: 6-12 years Female Male ab: Careful consideration of motor impairments, such as those documented in autism, can afford valuable insights into the neurological basis of developmental disorders. Motor signs are highly quantifiable and reproducible and can serve as markers for deficits in parallel systems important for socialization and communication. Correlations of motor signs with anatomic MRI (aMRI) measures therefore offer an important means of investigating brain abnormalities contributing to autism. Prior aMRI studies have revealed increased cerebral volume in young children with autism, particularly in 'outer zone' radiate white matter; however functional correlates of these findings have not been reported. In this study, we examined whether radiate white matter within the primary motor cortex would predict impaired motor performance in children with autism. Subjects included children ages 8-12 years: 20 with autism, 36 typically developing (TD) controls and 20 clinical controls with attention-deficit/hyperactivity disorder (ADHD). Regional tissue volumes were measured using an automated tissue classification algorithm followed by a semi-automated parcellation method. Motor performance was assessed using the Physical and Neurologic Examination of Subtle Signs (PANESS), with higher scores indicating poorer performance. Independent linear regression analyses revealed that for TD controls there was a significant negative correlation between total PANESS score and primary motor cortex white matter volume in both the right and left hemispheres, such that increased white matter volume predicted improved motor skill. In contrast, children with autism showed a robust positive correlation between total PANESS score and left hemisphere primary motor and premotor white matter volumes, such that increased white matter volume predicted poorer motor skill. No significant correlations were found for ADHD. Multivariate regression analyses revealed that the correlation between PANESS score and left motor cortex white matter volume in children with autism significantly differed from those in both ADHD and TD children. The correlation in ADHD did not significantly differ from that in TD children. The findings for the first time demonstrate an association between increasing radiate white matter volume and functional impairment in children with autism, in this case basic motor skill impairment. The observed association, which appears specific to autism, may be representative of global patterns of brain abnormality that not only contribute to motor dysfunction in autism, but also deficits in socialization and communication that define the disorder. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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