Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances.
Chemical management programs strive to protect human health and the environment by accurately identifying persistent, bioaccumulative, toxic substances and restricting their use in commerce. The advance of these programs is challenged by the reality that few empirical data are available for the tens...
| Publicado en: | Environmental Health Perspectives Vol. 115; no. 2; pp. 255 - 262 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Feb2007
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105983548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105983548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Feb2007 vid: 115 iid: 2 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105983548 2009516994 NLM17384774 105983548 ppf: 255 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Workgroup report: review of fish bioaccumulation databases used to identify persistent, bioaccumulative, toxic substances. aug: au: Wesibrod AV Burkhard LP Arnot J Mekenyan O Howard PH Russom C Boethling R Sakuratani Y Traas T Bridges T Lutz C Bonnell M Woodburn K Parkerton T affil: Central Product Safety, Procter & Gamble Company, Cincinnati, Ohio sug: subj: Environmental Pollutants Analysis Fish Metabolism Resource Databases Animals Environmental Monitoring Environmental Pollutants Metabolism Environmental Pollutants Models, Biological Models, Theoretical Risk Assessment ab: Chemical management programs strive to protect human health and the environment by accurately identifying persistent, bioaccumulative, toxic substances and restricting their use in commerce. The advance of these programs is challenged by the reality that few empirical data are available for the tens of thousands of commercial substances that require evaluation. Therefore, most preliminary assessments rely on model predictions and data extrapolation. In November 2005, a workshop was held for experts from governments, industry, and academia to examine the availability and quality of in vivo fish bioconcentration and bioaccumulation data, and to propose steps to improve its prediction. The workshop focused on fish data because regulatory assessments predominantly focus on the bioconcentration of substances from water into fish, as measured using in vivo tests or predicted using computer models. In this article we review of the quantity, features, and public availability of bioconcentration, bioaccumulation, and biota--sediment accumulation data. The workshop revealed that there is significant overlap in the data contained within the various fish bioaccumulation data sources reviewed, and further, that no database contained all of the available fish bioaccumulation data. We believe that a majority of the available bioaccumulation data have been used in the development and testing of quantitative structure--activity relationships and computer models currently in use. Workshop recommendations included the publication of guidance on bioconcentration study quality, the combination of data from various sources to permit better access for modelers and assessors, and the review of chemical domains of existing models to identify areas for expansion. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|