Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm.
Background: Nanotechnology offers great promise in many industrial applications. However, little is known about the health effects of manufactured nanoparticles, the building blocks of nanomaterials.Objectives: Titanium dioxide (TiO[2]) nanoparticles with a primary size of 2-5 nm have not been studi...
| Publicado en: | Environmental Health Perspectives Vol. 115; no. 3; pp. 397 - 403 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Mar2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105983759&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105983759 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Mar2007 vid: 115 iid: 3 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 105983759 105983759 2009539487 10.1289/ehp.9469 NLM17431489 105983759 ppf: 397 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. aug: au: Grassian VH O'Shaughnessy PT Adamcakova-Dodd A Pettibone JM Thorne PS affil: Department of Chemistry, University of Iowa, Iowa City, IA 52242; vicki-grassian@uiowa.edu sug: subj: Inhalation Exposure Lung Drug Effects Nanotechnology Titanium Animal Studies Animals Body Fluids Body Fluids Immunology Cytokines Immunology Environmental Exposure Leukocyte Count Lung Immunology Macrophages Drug Effects Macrophages Immunology Male Mice Particle Size Titanium Administration and Dosage Male ab: Background: Nanotechnology offers great promise in many industrial applications. However, little is known about the health effects of manufactured nanoparticles, the building blocks of nanomaterials.Objectives: Titanium dioxide (TiO[2]) nanoparticles with a primary size of 2-5 nm have not been studied previously in inhalation exposure models and represent some of the smallest manufactured nanoparticles. The purpose of this study was to assess the toxicity of these nanoparticles using a murine model of lung inflammation and injury.Materials and Methods: The properties of TiO[2] nanoparticles as well as the characteristics of aerosols of these particles were evaluated. Mice were exposed to TiO[2] nanoparticles in a whole-body exposure chamber acutely (4 hr) or subacutely (4 hr/day for 10 days). Toxicity in exposed mice was assessed by enumeration of total and differential cells, determination of total protein, lactate dehydrogenase (LDH) activity and inflammatory cytokines in bronchoalveolar lavage (BAL) fluid. Lungs were also evaluated for histopathologic changesResults: Mice exposed acutely to 0.77 or 7.22 mg/m[3] nanoparticles demonstrated minimal lung toxicity or inflammation. Mice exposed subacutely (8.88 mg/m[3]) and necropsied immediately and at week 1 or 2 postexposure had higher counts of total cells and alveolar macrophages in the BAL fluid compared with sentinels. However, mice recovered by week 3 postexposure. Other indicators were negative.Conclusions: Mice subacutely exposed to 2-5 nm TiO[2] nanoparticles showed a significant but moderate inflammatory response among animals at week 0, 1, or 2 after exposure that resolved by week 3 postexposure. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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