The beneficial effects of dichloroacetate in acute limb ischemia.
Objective: The purpose of this study was to determine the effects of dichloroacetate (DCA) in acute limb ischemia.Methods: Anterior tibialis muscle samples of DCA-treated and control animals (Sprague Dawley rats) were collected and assayed for pyruvate dehydrogenase activity, lactate, adenosine trip...
| Publicado en: | Military Medicine Vol. 172; no. 6; pp. 628 - 634 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Jun2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105986333&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105986333 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: Jun2007 vid: 172 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 105986333 105986333 NLM17615846 2009620048 10.7205/milmed.172.6.628 NLM17615846 105986333 ppf: 628 ppct: 6 formats: fmt: @attributes: type: P tig: atl: The beneficial effects of dichloroacetate in acute limb ischemia. aug: au: Platz TA Wilson JS Kline JA Rushing G Parker JL Moore EM Southern FN Platz, Timothy A Wilson, Jeffrey S Kline, Jeffrey A Rushing, Greg Parker, Jaime L Moore, Erin M Southern, Fredrick N affil: Department of Vascular and Endovascular Surgery, Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708, USA sug: subj: Acetic Acid Therapeutic Use Compartment Syndromes Drug Therapy Ischemia Drug Therapy Acute Disease Adenosine Triphosphate Animals Compartment Syndromes Complications Ischemia Complications Muscle Fatigue Drug Effects Muscle, Skeletal Blood Supply Muscle, Skeletal Drug Effects Necrosis Physical Endurance Rats Reperfusion ab: Objective: The purpose of this study was to determine the effects of dichloroacetate (DCA) in acute limb ischemia.Methods: Anterior tibialis muscle samples of DCA-treated and control animals (Sprague Dawley rats) were collected and assayed for pyruvate dehydrogenase activity, lactate, adenosine triphosphate, and creatine phosphate using spectrophotometry. A physiograph was used to measure fatigability. In an ischemia/reperfusion model using New Zealand rabbits, serum lactate and end-tidal CO2 were compared. Skeletal muscle was evaluated microscopically for muscle necrosis.Results: DCA administration resulted in a 50% increase in pyruvate dehydrogenase activity (p = 0.025), reversal of the increase in lactate levels seen during acute limb ischemia (p = 0.41), a significant increase in the time to skeletal muscle fatigue (p = 0.05), a trend toward increased adenosine triphosphate (p = 0.07), and a significant increase in creatine phosphate (p < 0.02). DCA treatment resulted in a decrease in serum lactate (p < 0.01) and end-tidal CO2 (p < 0.001).Conclusion: In acute limb ischemia and reperfusion, DCA administration provides metabolic protection to skeletal muscle. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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