Helicobacter pylori culture and antimicrobial resistance in Iran.
Objective: Helicobacter pylori is considered as an important etiologic factor in pathogenesis of peptic ulcer disease, chronic gastritis and gastric cancer. To eradicate this micro-organism, numerous regimens containing various antimicrobial agents have been suggested. However, H pylori antimicrobia...
| Publicado en: | Indian Journal of Pediatrics Vol. 74; no. 2; pp. 127 - 131 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=105991715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 105991715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00195456 1CQL jtl: Indian Journal of Pediatrics issn: 00195456 maglogo: N pubinfo: dt: Feb2007 vid: 74 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 105991715 105991715 NLM17337822 2009646718 10.1007/s12098-007-0003-4 NLM17337822 105991715 ppf: 127 ppct: 4 formats: tig: atl: Helicobacter pylori culture and antimicrobial resistance in Iran. aug: au: Fallahi GH Maleknejad S Fallahi, Gholam-Hossein Maleknejad, Shohreh affil: Department of Gastroenterology, Children Medical Centre, Tehran University of Medical Science, Tehran, Iran sug: subj: Antibiotics Pharmacodynamics Drug Resistance, Microbial Helicobacter Infections Diagnosis Helicobacter Infections Drug Therapy Helicobacter Pylori Drug Effects Metronidazole Pharmacodynamics Adolescence Antibiotics Therapeutic Use Biopsy, Needle Child Child, Preschool Dyspepsia Diagnosis Dyspepsia Etiology Female Gastroscopy Helicobacter Pylori Immunohistochemistry Male Metronidazole Therapeutic Use Microbial Culture and Sensitivity Tests Probability Prospective Studies Risk Assessment Sensitivity and Specificity Human Adolescent: 13-18 years Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Objective: Helicobacter pylori is considered as an important etiologic factor in pathogenesis of peptic ulcer disease, chronic gastritis and gastric cancer. To eradicate this micro-organism, numerous regimens containing various antimicrobial agents have been suggested. However, H pylori antimicrobial resistance is a leading factor to treatment failure and recurrence of the disease. The aim of the study was to evaluate the prevalence of H pylori resistance to metronidazole, clarithromycin, tetracycline, amoxicillin, erythromycin and furazolidone in authors pediatric patients.Methods: Antral biopsy of all pediatric patients with negative history of receiving anti-H pylori regimen and endoscopic findings of nodular gastritis or peptic ulcer without previous history of NSAID consumption, burning and trauma were performed for H pylori histology, urease test and culture. All positive cultures were tested for antimicrobial susceptibility.Results: Twenty four patients (14 male and 10 female) between 3.5 and 14 years of age were culture positive. 54.16% of the isolates were resistant to metronidazole, 8.33% to amoxicillin, 4.16% to erythromycin and 4.16% to clarithromycin. None of authors patients were resistant to tetracycline and furazolidone.Conclusion: H. pylori antimicrobial resistance could be a major contributor to failure of H pylori eradication. Continuous prospective surveillance of H. Pylori is essential. Moreover, culture and antimicrobial susceptibility test is recommended for resistant cases after the first failure to therapy. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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