Nonsense mutations in hERG cause a decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long-QT syndrome.

Background: Long-QT syndrome type 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG). More than 30% of the LQT2 mutations result in premature termination codons. Degradation of premature termination codon-containing mRNA transcripts by nonsense-mediated mRNA decay is incr...

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Publicado en:	Circulation Vol. 116; no. 1; pp. 17 - 25
Autores principales:	Gong Q, Zhang L, Vincent GM, Horne BD, Zhou Z, Gong, Qiuming, Zhang, Li, Vincent, G Michael, Horne, Benjamin D, Zhou, Zhengfeng
Formato:	research Journal Article
Publicado:	Lippincott Williams & Wilkins 7/3/2007
Acceso en línea:	Ver este registro en EBSCOhost