Pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin treatment of chronic hepatitis C.
Interferon therapy is the cornerstone of chronic hepatitis C treatment. Side effects of interferon include possible triggering or exacerbation of immune diseases in consequence of immunomodulatory effects. We describe the unique case, in which pyoderma gangrenosum and exacerbation of psoriasis were...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 19; no. 9; pp. 811 - 816 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2007 Sep
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106009424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106009424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2007 Sep vid: 19 iid: 9 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106009424 106009424 NLM17700270 2009653652 10.1097/meg.0b013e32816e070b NLM17700270 106009424 ppf: 811 ppct: 5 formats: tig: atl: Pyoderma gangrenosum and exacerbation of psoriasis resulting from pegylated interferon alpha and ribavirin treatment of chronic hepatitis C. aug: au: Yurci A Guven K Torun E Gursoy S Baskol M Akgun H Ozbakir O Yucesoy M Yurci, Alper Guven, Kadri Torun, Edip Gursoy, Sebnem Baskol, Mevlut Akgun, Hulya Ozbakir, Omer Yucesoy, Mehmet affil: Department of Gastroenterology, Erciyes University, School of Medicine, Kayseri, Turkey sug: subj: Antiviral Agents Adverse Effects Dermatitis Medicamentosa Etiology Glycols Hepatitis C, Chronic Drug Therapy Interferons Psoriasis Chemically Induced Pyoderma Gangrenosum Chemically Induced Antiviral Agents Therapeutic Use Dermatitis Medicamentosa Pathology Drug Therapy, Combination Female Middle Age Psoriasis Pathology Pyoderma Gangrenosum Pathology Ribavirin Adverse Effects Ribavirin Therapeutic Use Middle Aged: 45-64 years Female ab: Interferon therapy is the cornerstone of chronic hepatitis C treatment. Side effects of interferon include possible triggering or exacerbation of immune diseases in consequence of immunomodulatory effects. We describe the unique case, in which pyoderma gangrenosum and exacerbation of psoriasis were developed 8 weeks after pegylated interferon alpha 2a and ribavirin therapy in a 45-year-old woman. The therapy had to be stopped on account of pyoderma gangrenosum and exacerbation of psoriasis in spite of a biochemical response to the therapy for hepatitis C. The evolution was favorable after stopping treatment. Therefore, we propose this would suggest a possible autoimmune mechanism for the development of pyoderma gangrenosum and exacerbation of psoriasis with pegylated interferon therapy. A susceptible patient, who has an autoimmune disease before interferon therapy, had to be informed that interferons may induce de novo or exacerbate existing immune diseases by immunomodulatory actions. To the best of our knowledge, this is the first case report of pyoderma gangrenosum and psoriasis that resulted from pegylated interferon alpha 2a and ribavirin treatment of chronic hepatitis C. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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