Effect of Antiarrhythmic Drug Therapy on the Incidence of Shocks in Patients who Receive an Implantable Cardioverter Defibrillator after a Single Episode of Sustained Ventricular Tachycardia/Fibrillation.
Seventy-four patients (16 women, 58 men, age 58 ± 11 years, mean ± standard deviation) who received an implantable cardioverter defibrillator (ICD) after experiencing a single episode of ventricular tachycardia or ventricular fibrillation were followed to determine if antiarrhythmic drug therapy aff...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 14; no. 11; pp. 1586 - 1593 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Nov1991
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106034856&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106034856 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Nov1991 vid: 14 iid: 11 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106034856 2009408058 NLM1721147 106034856 ppf: 1586 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effect of Antiarrhythmic Drug Therapy on the Incidence of Shocks in Patients who Receive an Implantable Cardioverter Defibrillator after a Single Episode of Sustained Ventricular Tachycardia/Fibrillation. aug: au: Kou WH Kirsh MM Bolling SF Stirling M Kadish AH De Buitleir M Calkins H Lewis RR Morady F sug: ab: Seventy-four patients (16 women, 58 men, age 58 ± 11 years, mean ± standard deviation) who received an implantable cardioverter defibrillator (ICD) after experiencing a single episode of ventricular tachycardia or ventricular fibrillation were followed to determine if antiarrhythmic drug therapy affects the incidence of ICD discharges. Thirty-three patients (group A) were treated with an antiarrhythmic drug that was either untested or previously demonstrated during electropharmacological testing to be ineffective in suppressing the induction of ventricular tachycardia. Forty-one patients (group B) were not treated with an antiarrhythmic drug. There were no significant differences between the two groups in regards to age, sex, incidence of coronary artery disease, left ventricular function or the type of ICD pulse generator used. During a mean follow-up of 14 months for the entire cohort, 15 patients (46%) in group A and 18 patients [44%) in group B experienced at least one ICD shock. The time to the first appropriate shock (5 ± 5 months in both groups) and the frequency of ICD shocks (0.3 ± 0.2/month in group A vs 0.4 ± 0.5/month in group B) were similar in both groups. The incidence of syncope at the time of lCD discharge was higher in group A than group B patients (31% vs 5%, P < 0.05). In conclusion, antiarrhythmic drugs that are untested or have failed electropharmacological testing do not appear to reduce the probability of ICD discharge over a short-term (mean 14 months) follow-up in patients who have had only one clinical episode of VT/VF and may increase the risk of syncope during ICD discharge. Studies with a larger sample size and longer follow-up period will be needed to confirm these findings. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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