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Hyperoxia improves microvascular perfusion in a murine wound model.

There is a need for a noninvasive method that measures wound angiogenesis. Hyperoxia is known to increase the appearance of new blood vessels in wounds, yet no study has confirmed increases in wound bed perfusion with periodic hyperbaric oxygen (HBO) exposure. This study investigates whether laser D...

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Published in:Wound Repair & Regeneration Vol. 13; no. 3; pp. 303 - 309
Main Authors: Sheikh AY, Rollins MD, Hopf HW, Hunt TK
Format: Journal Article
Published: Wiley-Blackwell May/Jun2005
Online Access:View this record in EBSCOhost
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      issn: 10671927
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      dt: May/Jun2005
      vid: 13
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: Hyperoxia improves microvascular perfusion in a murine wound model.
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        au:
          Sheikh AY
          Rollins MD
          Hopf HW
          Hunt TK
      sug:
      ab: There is a need for a noninvasive method that measures wound angiogenesis. Hyperoxia is known to increase the appearance of new blood vessels in wounds, yet no study has confirmed increases in wound bed perfusion with periodic hyperbaric oxygen (HBO) exposure. This study investigates whether laser Doppler imaging is able to detect and quantify the enhancement of wound angiogenesis that is known to occur with intermittent HBO treatments. Full-thickness dorsal dermal wounds were created on mice randomized to hyperoxic (n = 14) and control (n = 15) groups. Hyperbaric oxygen was administered twice daily for 90 minutes each at 2.1 atmospheres for 7 days. Wound bed perfusion was measured by laser Doppler imaging on days 0, 7, and 10 postwounding. Wound blood flow increased significantly over baseline on day 7 and 10 in the hyperoxic group, but only on day 10 in the control group. Comparison between groups showed a 20% statistically significant increase in wound perfusion in HBO-treated animals compared to control on day 10 (p = 0.05). Laser Doppler imaging was able to detect and quantify the increase in wound bed perfusion resulting from intermittent HBO treatments and shows promise as a noninvasive measure of angiogenesis and wound healing.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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