Psychometric analysis in children with mental retardation due to perinatal hypoxia treated with fibroblast growth factor (FGF) and showing improvement in mental development.
Basic fibroblast growth factor (bFGF) has shown a neurotrophic effect in the neurons of several CNS areas. <em>In vivo</em>, it contributes to restore neurochemical and morphological deficits in different rodent models of brain damage, including rats with brain damage induced by hypoxia/ischemia whe...
| Publicado en: | Journal of Intellectual Disability Research Vol. 37; no. 6; pp. 507 - 521 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Dec1993
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106035568&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106035568 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09642633 EUL jtl: Journal of Intellectual Disability Research issn: 09642633 maglogo: Y pubinfo: dt: Dec1993 vid: 37 iid: 6 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106035568 2009409273 NLM8123997 106035568 ppf: 507 ppct: 14 formats: fmt: @attributes: type: P tig: atl: Psychometric analysis in children with mental retardation due to perinatal hypoxia treated with fibroblast growth factor (FGF) and showing improvement in mental development. aug: au: Aguilar LC Islas A Rosique P Hernandez B Portillo E Herrera JM Cortes R Cruz S Alfaro F Martin R Cantu JM sug: ab: Basic fibroblast growth factor (bFGF) has shown a neurotrophic effect in the neurons of several CNS areas. <em>In vivo</em>, it contributes to restore neurochemical and morphological deficits in different rodent models of brain damage, including rats with brain damage induced by hypoxia/ischemia when FGF was intramuscularly (i.m.) administered. Toxicological and immunological studies performed in rats, mice and volunteers showed no evidence of side-effects. Bovine FGF was i.m. administered in children with mental retardation caused by perinatal hypoxia, aged 1-15 years, at dosages of 0.4 or 0.28 ug kg-1, once or twice a month, over 7-12 months. Group A [n= 12; 6 treated (T), 6 controls (Ct)], group B (n=16; 8 T, 8 Ct) and group C (n = 67; 45 T, 22 Ct) were evaluated with the P. A. R. scale, the WISC-RM and the Gesell scale, respectively. Development increased significantly in treated children from groups A (P<0.02) and C (P<0.001), and IQ rose by more than 10 points (P<0.001) in group B patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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