Fiber orientation and cell-cell coupling influence ventricular fibrillation dynamics.
Cell Coupling Influences VF Dynamics. Introduction: The structure of ventricular fibrillation (VF) is influenced by regional differences in action potential durations and perhaps restitution kinetics and fiber anisotropy. The spatial organization of VF was investigated by measuring the cross-correla...
| Published in: | Journal of Cardiovascular Electrophysiology Vol. 14; no. 8; pp. 851 - 861 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Wiley-Blackwell
Aug2003
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106078927&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106078927 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Aug2003 vid: 14 iid: 8 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106078927 2009386894 NLM12890049 106078927 ppf: 851 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Fiber orientation and cell-cell coupling influence ventricular fibrillation dynamics. aug: au: Choi B Liu T Lavasani M Salama G sug: subj: Action Potentials Electrocardiography Methods Heart Conduction System Pathology Heart Conduction System Physiopathology Image Interpretation, Computer Assisted Methods Ventricular Fibrillation Pathology Ventricular Fibrillation Physiopathology Alcohols Pharmacodynamics Animals Cell Physiology Cells Pathology Female Heart Conduction System Drug Effects Heart Ventricle Drug Effects Heart Ventricle Pathology Heart Ventricle Physiopathology Rabbits Spectrometry, Fluorescence Methods Statistics Female ab: Cell Coupling Influences VF Dynamics. Introduction: The structure of ventricular fibrillation (VF) is influenced by regional differences in action potential durations and perhaps restitution kinetics and fiber anisotropy. The spatial organization of VF was investigated by measuring the cross-correlation (CC) and mutual information (MI) of membrane potential (V[sub m]) oscillations recorded from multiple sites. Methods and Results: Rabbit hearts (n = 6) were retrogradely perfused and stained with di-4-ANEPPS, and VF was elicited by burst pacing. V[sub m] oscillations were recorded optically from multiple locations on the epicardium using a 16 x 16 photodiode array or a 72 x 78 CCD camera. The spatial organization of VF was investigated by calculating the maximum CC (CC[sub max]) and MI (MI[sub max]) that can be obtained between any two sites. CC[sub max] and MI[sub max] were extended to all pixels and served as indices of the similarities between V[sub m] transients at a reference pixel and all other pixels on the map. We found that maps of CC[sub max] and MI[sub max] did not contain discrete regions with high CC or MI. However, CC[sub max] and MI[sub max] decreased monotonically with increasing distance between any arbitrarily chosen reference pixel and all other pixels. In VF, maps of CC[sub max] and MI[sub max] revealed elliptical gradients of CC and MI that were closely aligned with fiber orientation, with major axis at 127°± 8° on the left ventricles. Conclusion: CC and MI analysis in fibrillation provides new evidence that anisotropy of fiber orientation and cell-cell coupling have a direct influence on VF dynamics. (J Cardiovasc Electrophysiol, Vol. 14, pp. 851-860, August 2003). pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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