Exclusion of Linkage to the HLA Region in Ninety Multiplex Sibships with Autism.
Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 29; no. 3; pp. 195 - 202 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106080014&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106080014 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jun1999 vid: 29 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 106080014 106080014 2009389988 10.1023/a:1023075904742 NLM10425582 106080014 ppf: 195 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Exclusion of Linkage to the HLA Region in Ninety Multiplex Sibships with Autism. aug: au: Rogers T Kalaydjieva L Hallmayer J Petersen PB Nicholas P Pingree C Mcmahon WM Spiker D Lotspeich L Kraemer H Mccague P Dimiceli S Nouri N Peachy T Yang J Hinds D Risch N Myers RM sug: subj: Autism Spectrum Disorder Genetics HLA Antigens Adolescence Adult Alleles Child Child, Preschool Chromosome Disorders Chromosomes Disease Susceptibility Epidemiological Research Female Genetic Markers Physiology Genotype Male Polymerase Chain Reaction Human Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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