Extramammary paget disease of the scrotum with features of bowen disease.
The scrotum is an uncommon site for the presentation of extramammary Paget disease (EMPD). We describe a case of EMPD that was discovered in a patient who had been previously diagnosed and treated for squamous cell carcinoma in situ of the scrotum 3 years earlier. Pathologic examination of the curre...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 128; no. 1; pp. 84 - 87 |
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| Autores principales: | , , , |
| Formato: | case study Journal Article |
| Publicado: |
College of American Pathologists
Jan2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106080647&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106080647 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Jan2004 vid: 128 iid: 1 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 106080647 106080647 2009391783 10.5858/2004-128-84-epdots NLM14692806 106080647 ppf: 84 ppct: 3 formats: fmt: @attributes: type: P tig: atl: Extramammary paget disease of the scrotum with features of bowen disease. aug: au: Quinn AM Sienko A Basrawala Z Campbell SC sug: subj: Genital Neoplasms, Male Pathology Neoplasms, Ductal, Lobular, and Medullary Pathology Scrotum Pathology Carcinoma, Squamous Cell Pathology Diagnosis, Differential Genital Neoplasms, Male Diagnosis Male Middle Age Neoplasms, Ductal, Lobular, and Medullary Diagnosis Middle Aged: 45-64 years Male ab: The scrotum is an uncommon site for the presentation of extramammary Paget disease (EMPD). We describe a case of EMPD that was discovered in a patient who had been previously diagnosed and treated for squamous cell carcinoma in situ of the scrotum 3 years earlier. Pathologic examination of the current scrotectomy specimen revealed an erythematous patch with areas of pale induration. Microscopic examination revealed areas with the characteristic histology of Paget disease adjacent to areas characteristic of Bowen disease. Immunohistochemical findings demonstrated a strong expression of carcinoembryonic antigen, cytokeratin 7, and low-molecular-weight cytokeratins (CAM 5.2) in both of these areas, giving support to the overall diagnosis of EMPD. High-molecular-weight cytokeratins (34[beta]E12) were uncharacteristically expressed in the cytoplasm of the Paget cells with equal or greater strength than in the surrounding keratinocytes, suggesting some degree of squamous differentiation. Very few publications have reported the coexistence of EMPD with squamous cell carcinoma in situ, occurring mostly in the vulva. To our knowledge, our case is the first report of scrotal EMPD with features of Bowen disease. Our findings support the theory that primary EMPD arises multifocally from multipotential epidermal cells. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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