Cellular proliferative fraction measured with topoisomerase iia predicts Malignancy in endocrine pancreatic tumors.
Context.-Endocrine pancreatic tumors (EPTs) are rare lesions with varying biological behavior. Establishing malignancy is a challenge for clinicians and pathologists. Objective.-To establish the role of proliferative, apoptotic, angiogenic, and hormonal markers as predictors of malignancy in EPTs. D...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 128; no. 4; pp. 426 - 430 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
College of American Pathologists
Apr2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106081480&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106081480 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Apr2004 vid: 128 iid: 4 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 106081480 106081480 2009394720 10.5858/2004-128-426-cpfmwt NLM15043465 106081480 ppf: 426 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Cellular proliferative fraction measured with topoisomerase iia predicts Malignancy in endocrine pancreatic tumors. aug: au: Diaz-Rubio JL Duarte-Rojo A Saqui-Salces M Gamboa-Dominguez A Robles-Diaz G sug: subj: Enzymes Analysis Gastrinoma Pathology Insulinoma Pathology Pancreatic Neoplasms Pathology Proteins Analysis Tumor Markers, Biological Analysis Adolescence Adult Aged Antigens, Tumor Apoptosis Cell Physiology Endothelial Growth Factors Analysis Female Gastrinoma Blood Supply Gastrinoma Genetic Techniques Insulinoma Blood Supply Insulinoma Male Middle Age Neoplasm Invasiveness Neovascularization, Pathologic Pathology Pancreatic Neoplasms Prognosis Proteins ROC Curve Sensitivity and Specificity Human Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Context.-Endocrine pancreatic tumors (EPTs) are rare lesions with varying biological behavior. Establishing malignancy is a challenge for clinicians and pathologists. Objective.-To establish the role of proliferative, apoptotic, angiogenic, and hormonal markers as predictors of malignancy in EPTs. Design.-Paraffin-embedded EPT samples were studied for prognostic markers. Patients.-Twenty-one consecutive patients with a diagnosis of EPT. Main Outcome Measures.-The proliferative fraction (topoisomerase Ii[alpha]), microvascular density (CD34), vascular endothelial growth factor expression, and estrogen receptor-beta (ER[beta]) expression were studied by immunohistochemistry on all EPTs. Apoptosis was also assessed with terminal deoxynucleotidyl transferase nick-end labeling. Results.-We identified 13 benign and 8 malignant tumors. Topoisomerase II[alpha] was significantly increased in malignant tumors ( P = .001), while there were no differences in apoptosis, microvascular density, or vascular endothelial growth factor expression in association with malignancy. No correlation could be identified between microvascular density and vascular endothelial growth factor expression, and ER[beta] was not detected. A receiver operating characteristic curve for topoisomerase II[alpha] disclosed that above a labeling index of 13, the test had 88% sensitivity and 100% specificity for predicting malignancy. Conclusion.-Cellular proliferation measured with topoisomerase II[alpha] is a simple prognostic marker for malignancy in EPTs, unlike apoptosis, angiogenesis, or the presence of ER[beta], which were not associated with malignant behavior. These findings designate a defined field for future research on endocrine pancreatic carcinogenesis and a possible target for chemotherapeutic agents. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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