Chemopreventive Effects of Cuminum cyminum in Chemically Induced Forestomach and Uterine Cervix Tumors in Murine Model Systems.
Lately a strong correlation has been established between diet and cancer. For ages, cumin has been a part of the diet. It is a popular spice regularly used as a flavoring agent in a number of ethnic cuisines. In the present study cancer chemopreventive potentials of different doses of a cumin seed-m...
| Publicado en: | Nutrition & Cancer Vol. 47; no. 2; pp. 171 - 181 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
2003
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106081708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106081708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2003 vid: 47 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106081708 106081708 2009395308 NLM15087270 106081708 ppf: 171 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Chemopreventive Effects of Cuminum cyminum in Chemically Induced Forestomach and Uterine Cervix Tumors in Murine Model Systems. aug: au: Dhanalakshmi S Méndiz E Rao AR Kale RK sug: subj: Antineoplastic Agents Therapeutic Use Cervix Neoplasms Prevention and Control Medicine, Herbal Plant Extracts Therapeutic Use Plants Stomach Neoplasms Prevention and Control Animal Studies Cervix Neoplasms Chemically Induced Diet Dose-Response Relationship, Drug Female Hemeproteins Metabolism Lipid Peroxidation Drug Effects Liver Liver Drug Effects Mice Oxidative Stress Drug Effects Oxidoreductases Metabolism Random Assignment Stomach Neoplasms Chemically Induced Superoxide Dismutase Metabolism Transferases Metabolism Female ab: Lately a strong correlation has been established between diet and cancer. For ages, cumin has been a part of the diet. It is a popular spice regularly used as a flavoring agent in a number of ethnic cuisines. In the present study cancer chemopreventive potentials of different doses of a cumin seed-mixed diet were evaluated against benzo(a)pyrene [B(a)P]-induced forestomach tumorigenesis and 3-methylcholanthrene (MCA)-induced uterine cervix tumorigenesis. Results showed a significant inhibition of stomach tumor burden (tumors per mouse) by cumin. Tumor burden was 7.33 ± 2.10 in the B(a)P-treated control whereas it reduced to 3.10 ± 0.57 (P < 0.001) by a 2.5% dose and 3.11 ± 0.60 (P <0.001) by a 5% dose of cumin seeds. Cervical carcinoma incidence, compared with the MCA-treated control group (66.67%), reduced to 27.27% (P < 0.05) by a diet of 5% cumin seeds and to 12.50% (P < 0.05) by a diet of 7.5% cumin seeds. The effect of 2.5 and 5% cumin seed-mixed diets was also examined on carcinogen/xenobiotic metabolizing phase I and phase II enzymes, antioxidant enzymes, glutathione content, lactate dehydrogenase (LDH), and lipid peroxidation in the liver of Swiss albino mice. Levels of cytochrome P-450 (cyt P-450) and cytochrome b5 (cyt b5) were significantly augmented (P < 0.05) by the 2.5% dose of cumin seed diet. The levels of cyt P-450 reductase and cyt b5 reductase were increased (significance level being from P < 0.05 to P < 0.01) by both doses of cumin. Among the phase II enzymes, glutathione S-transferase specific activity increased (P < 0.005) by the 5% dose, whereas that of DT-diaphorase increased significantly (P < 0.05) by both doses used (2.5 and 5%). In the antioxidant system, significant elevation of the specific activities of super-oxide dismutase (P < 0.01) and catalase (P < 0.05) was observed with the 5% dose of cumin. The activities of glutathione peroxidase and glutathione reductase remained unaltered by both doses of cumin. The level of reduced elutathione measured as nonprotein sulfhydryl content was elevated (significance level being from P < 0.05 to P < 0.01) by both doses of cumin. Lipid peroxidation measured as formation of MDA production showed significant inhibition (P < 0.05 to P < 0.01) by both doses of cumin. LDH activity remained unaltered by both doses of cumin. The results strongly suggest the cancer chemopreventive potentials of cumin seed and could be attributed to its ability to modulate carcinogen metabolism. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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