Surface contamination of chemotherapy drug vials and evaluation of new vial-cleaning techniques: Results of three studies.
Purpose. The results of three studies that describe the external contamination of chemotherapy drug vials are presented. New techniques for the improved decontamination of vials containing cisplatin are also described. Summary. Study 1 evaluated the external contamination of drug vials with cyclopho...
| Publicado en: | American Journal of Health-System Pharmacy Vol. 62; no. 5; pp. 475 - 476 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Oxford University Press / USA
3/1/2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106084239&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106084239 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10792082 1X3 jtl: American Journal of Health-System Pharmacy issn: 10792082 maglogo: N pubinfo: dt: 3/1/2005 vid: 62 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106084239 2009404182 10.1093/ajhp/62.5.475 NLM15745910 106084239 ppf: 475 ppct: 1 formats: fmt: @attributes: type: P tig: atl: Surface contamination of chemotherapy drug vials and evaluation of new vial-cleaning techniques: Results of three studies. aug: au: Connor TH Sessink PJ Harrison BR Pretty JR Peters BG Alfaro RM Bilos A Beckmann G Bing MR Anderson LM Dechristoforo R sug: subj: Antineoplastic Agents Decontamination, Hazardous Materials Methods Antineoplastic Agents Analysis Drug Packaging Equipment Contamination Prevention and Control Pharmacy Service Human ab: Purpose. The results of three studies that describe the external contamination of chemotherapy drug vials are presented. New techniques for the improved decontamination of vials containing cisplatin are also described. Summary. Study 1 evaluated the external contamination of drug vials with cyclophosphamide and ifosfamide in a pharmacy setting. Widespread contamination of the outside of drug vials was found with each drug. Study 2 evaluated the surface contamination of drug vials with cyclophosphamide and fluorouracil in three pharmacies. Sporadic contamination with fluorouracil was detected, while cyclophosphamide was found on most vials. In study 3, investigators compared the decontamination abilities of a standard decontamination procedure at the manufacturer level with an improved decontamination procedure and the use of sleeves to further decrease contamination. Though the methods of each study reported herein differed, the outcomes were similar. All chemotherapy drug vials studied demonstrated levels of contamination with the drug well above the limit of detection. Improved decontamination procedures, combined with the use of protective sleeves, reduced the level of platinum contamination by 90%, suggesting that standard decontamination procedures should be reconsidered. Conclusion. The results of these studies are consistent with several others that have reported contamination of the outside surface of drug vials for a number of chemotherapy drugs. Contamination can be reduced by using decontamination equipment and protective sleeves during the manufacturing process. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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