Fibrillation is More Complex in the Left Ventricle than in the Right Ventricle.
Introduction: The mechanisms that maintain ventricular fibrillation (VF) are not completely understood. It has been proposed that increased ventricular wall thickness destabilizes VF wavefronts and therefore is an important determinant of VF activation patterns. We hypothesized that if this is the c...
| Publicado en: | Journal of Cardiovascular Electrophysiology Vol. 11; no. 12; pp. 1364 - 1372 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2000
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106084718&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106084718 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Dec2000 vid: 11 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106084718 2009405238 NLM11196560 106084718 ppf: 1364 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Fibrillation is More Complex in the Left Ventricle than in the Right Ventricle. aug: au: Rogers JM Huang J Pedoto RW Walker RG Smith WM Ideker RE sug: subj: Ventricular Dysfunction, Left Physiopathology Ventricular Dysfunction, Right Physiopathology Ventricular Fibrillation Physiopathology Action Potentials Animals Electrocardiography Electrodes, Implanted Heart Conduction System Physiopathology Heart Function Tests Heart Ventricle Pathology Myocardium Pathology Pericardium Physiopathology Signal Processing, Computer Assisted Swine Ventricular Dysfunction, Left Complications Ventricular Dysfunction, Left Pathology Ventricular Dysfunction, Right Complications Ventricular Dysfunction, Right Pathology Ventricular Fibrillation Complications Ventricular Fibrillation Pathology ab: Introduction: The mechanisms that maintain ventricular fibrillation (VF) are not completely understood. It has been proposed that increased ventricular wall thickness destabilizes VF wavefronts and therefore is an important determinant of VF activation patterns. We hypothesized that if this is the case, then VF patterns on the thin-walled right ventricle (RV) should be simpler than those on the thick-walled left ventricle (LV). Methods and Results: In seven open chest pigs, we mapped VF simultaneously from two epicardial recording arrays, one on the RV and one on the LV. Each array contained 504 unipolar electrodes (in a 21 x 24 grid) spaced by 2 mm. We used specialized pattern analysis methods to compute quantitative descriptors of RV and LV activation patterns. Our data show that VF is more organized in the RV than the LV, containing fewer, larger wavefronts that follow fewer distinct pathways and are less likely to fragment or collide with other wavefronts. The incidence, size, and cycle length of reentrant circuits were similar in the two ventricles, but RV reentry persisted for more cycles. These results are not predicted by the differences in electrophysiologic properties between LV and RV that have been reported In mammalian hearts. Conclusion: The geometry of the ventricular wall, particularly wall thickness, is an important determinant of VF activation patterns. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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