Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants.
The population pharmacokinetics of phenobarbital was evaluated using 69 serum concentration measurements obtained from the routine phenobarbital monitoring of 35 neonates and infants. The data were analysed using the nonlinear mixed effects model. A one-compartment open pharmacokinetic model with fi...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 30; no. 2; pp. 159 - 164 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106084789&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106084789 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Apr2005 vid: 30 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106084789 2009405466 10.1111/j.1365-2710.2005.00619.x NLM15811169 106084789 ppf: 159 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants. aug: au: Yukawa E Suematsu F Yukawa M Minemoto M sug: subj: Clinical Trials Methods Phenobarbital Pharmacokinetics Administration, Rectal Aging Aging Drug Effects Biological Availability Body Weight Drug Effects Body Weight Physiology Female Infant, Newborn Japan Ethnology Male Metabolic Clearance Rate Drug Effects Metabolic Clearance Rate Physiology Phenobarbital Administration and Dosage Phenobarbital Blood Retrospective Design Suppositories Suppositories Administration and Dosage Suppositories Pharmacokinetics Human Infant, Newborn: birth-1 month Female Male ab: The population pharmacokinetics of phenobarbital was evaluated using 69 serum concentration measurements obtained from the routine phenobarbital monitoring of 35 neonates and infants. The data were analysed using the nonlinear mixed effects model. A one-compartment open pharmacokinetic model with first-order elimination was used. Covariates screened were current bodyweight (TBW), gestational age, postnatal age (PNA), postconceptional age and gender. The final pharmacokinetic parameters were CL/F(mL/h) = 3·41·TBW (kg) + 1·64. PNA (weeks),Vd/F(L) = 1·09 TBW. (kg), andF = 0·406 for oral administration andF = 1 for suppository. Application of the findings in this study to patient care may permit selection of an appropriate initial maintenance dosage to achieve target phenobarbital concentrations, thus enabling the clinician to achieve the desired therapeutic effect in neonates and infants. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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