Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats.
Abstract: Epidemiologic studies suggest that dietary complex carbohydrates are protective against colorectal cancer but dietary protein may increase risk. However, experimental data to support these relationships are scant. We have shown in rats that consumption of a high-protein (25% casein) diet f...
| Publicado en: | Nutrition & Cancer Vol. 51; no. 1; pp. 45 - 52 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106084859&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106084859 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2005 vid: 51 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106084859 106084859 2009405710 10.1207/s15327914nc5101_7 NLM15749629 106084859 ppf: 45 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Resistant starch attenuates colonic DNA damage induced by higher dietary protein in rats. aug: au: Toden S Bird AR Topping DL Conlon MA sug: subj: Colon Drug Effects Dietary Proteins Administration and Dosage DNA Drug Effects Glucans Administration and Dosage Glucans Metabolism Animal Studies Cell Physiology Drug Effects Colon Colon Pathology Dietary Proteins Adverse Effects Electrophoresis, Agar Gel Fatty Acids, Volatile Analysis Feces Intestinal Mucosa Intestinal Mucosa Drug Effects Male Phenols Analysis Random Assignment Rats Male ab: Abstract: Epidemiologic studies suggest that dietary complex carbohydrates are protective against colorectal cancer but dietary protein may increase risk. However, experimental data to support these relationships are scant. We have shown in rats that consumption of a high-protein (25% casein) diet for 4 wk resulted in a twofold increase in damage to colonocyte DNA compared with a low-protein (15% casein) diet. This was associated with thinning of the colonic mucous barrier and increased levels of fecal p-cresol. Addition of resistant starch as a high-amylose maize starch to the diet increased cecal short-chain fatty acid pools and attenuated DNA damage, suggesting protection against genotoxic agents. In humans, this could translate to altered risk of colonic cancer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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