Atrial natriuretic peptide during different pacing modes in a comparison with hemodynamic changes.
The study investigates the response of atrial natriuretic peptide (ANP) to different cardiac pacing modes in comparison with hemodynamic changes. Ten patients underwent Swan-Ganz catheterization during pacemaker implant. Atrioventricular and ventricular pacing were performed consecutively at three p...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 13; no. 4; pp. 432 - 443 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
Apr1990
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106086718&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106086718 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Apr1990 vid: 13 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106086718 2009412357 NLM1692127 106086718 ppf: 432 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Atrial natriuretic peptide during different pacing modes in a comparison with hemodynamic changes. aug: au: Baratto MT Berti S Clerico A Fommei E Del Chicca MG Contini C sug: subj: Atrial Natriuretic Factor Blood Cardiac Pacing, Artificial Methods Hemodynamics Physiology Aged Aged, 80 and Over Atrioventricular Node Blood Pressure Physiology Cardiac Output Physiology Female Heart Block Therapy Heart Rate Physiology Heart Ventricle Male Middle Age Pulmonary Artery Physiopathology Pulmonary Wedge Pressure Physiology Sick Sinus Syndrome Therapy Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: The study investigates the response of atrial natriuretic peptide (ANP) to different cardiac pacing modes in comparison with hemodynamic changes. Ten patients underwent Swan-Ganz catheterization during pacemaker implant. Atrioventricular and ventricular pacing were performed consecutively at three pacing rate levels (80, 100, and 110 ppm). Blood samples were taken from the pulmonary artery for ANP determination, bath basally and at the end of each pacing period. Concomitantly, mean pulmonary capillary wedge pressure (PCWP) and mean pulmonary artery pressure (PAP) were measured. Cardiac output (CO) was determined by thermodilution both basally and during the 110 ppm steps. During atrioventricular pacing, whereas no significant changes were observed for ANP, PCWP and PAP, CO increased significantly (P < 0.0005). At the beginning of ventricular pacing hemodynamic parameters and ANP levels were comparable with those of baseline conditions. During subsequent ventricular pacing PCWP and ANP increased significantly at the 110 ppm rate step (P < 0.05). PAP did not change significantly, whereas CO decreased in all cases (P < 0.01). A positive correlation was observed between ANP and PCWP during ventricular (P < 0.001), but not atrioventricular pacing. The results, while confirming the hemodynamic advantages of atrioventricular pacing, point to a major stimulation of ANP secretion during ventricular pacing. This fact, together with the observed drop in CO and the correlation between ANP and PCWP, suggest that the increase of ANP in ventricular pacing may be the expression of a compensatory mechanism to the hemodynamic disadvantages of atrioventricular asynchrony. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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