Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action.
Nitroglycerin (NTG) administration occasionally leads to syncope due to severe hypotension and bradycardia. This reaction resembles neurocardiogenic syncope but it may occur when the patient is in the supine position. To address the possible role of prevailing autonomic tone and baroreflex control i...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 25; no. 5; pp. 828 - 833 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Wiley-Blackwell
May2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106087819&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106087819 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: May2002 vid: 25 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106087819 2009415783 NLM12049376 106087819 ppf: 828 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action. aug: au: Melenovsky V Wichterle D Malik J Simek J Hradec J Ceska R Malik M sug: subj: Nitroglycerin Adverse Effects Pressoreceptors Drug Effects Supine Position Physiology Syncope Chemically Induced Adult Blood Pressure Determination Blood Pressure Drug Effects Bradycardia Chemically Induced Electrocardiography Heart Rate Drug Effects Hypotension Chemically Induced Male Middle Age Nitroglycerin Administration and Dosage Nitroglycerin Pharmacodynamics Adult: 19-44 years Middle Aged: 45-64 years Male ab: Nitroglycerin (NTG) administration occasionally leads to syncope due to severe hypotension and bradycardia. This reaction resembles neurocardiogenic syncope but it may occur when the patient is in the supine position. To address the possible role of prevailing autonomic tone and baroreflex control in precipitation of NTG induced syncope, continuous noninvasive blood pressure and an EGG were taken shortly before NTG application in the supine position. Frequency-domain measures of heart rate variability (HBV) and noninvasive indices of baroreflex were compared between subjects who did (n = 6) and did not (n = 41) develop syncope after NTG. Both groups differed only in the phase shift (PCR) between oscillations of blood pressure and heart rate during controlled respiration (0.1 Hz). PCR was significantly delayed in subjects who developed syncope than in controls (- 99.3 ± 14.1 vs -65,5 ± 27,0 degrees, P = 0.002). Thus, subjects with prolonged PCR are prone to NTG induced syncope because of increased lagging and, consequently, less stable baroreflex control. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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