Source and role of endolymph macromolecules.
Evaluation of some 200 endolymph proteins indicates that they are predominantly derived from plasma. However, the profile of endolymph proteins is remarkably similar to that of perilymph and entirely different from that of plasma. This supports the current consensus that perilymph rather than plasma...
| Publicado en: | Acta Oto-Laryngologica Vol. 119; no. 3; pp. 293 - 297 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
4/23/99
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106093752&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106093752 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: 4/23/99 vid: 119 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106093752 2009436370 NLM10380730 106093752 ppf: 293 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Source and role of endolymph macromolecules. aug: au: Thalmann R Thalmann I sug: subj: Endolymph Metabolism Apolipoproteins Blood Endolymphatic Sac Physiology Membrane Proteins Physiology Vestibule, Labyrinth Physiology ab: Evaluation of some 200 endolymph proteins indicates that they are predominantly derived from plasma. However, the profile of endolymph proteins is remarkably similar to that of perilymph and entirely different from that of plasma. This supports the current consensus that perilymph rather than plasma is the (direct) source of endolymph. Although the levels of total protein of endolymph is extremely low, a few plasma-derived proteins, such as apolipoproteins J and D, are selectively enriched, conceivably for protection of cell membranes bounding the endolymphatic space. A small number of endolymph proteins, mostly glycosylated ones, are continually secreted into the endolymph by specialized epithelial cells, primarily for the maintenance of the structural and functional integrity of the extracellular superstructures comprising tectorial membrane, otoconial complex (membrane) and cupula. These complex macromolecules cannot be eliminated in the periphery of the compartment, but are transported to the endolymphatic sac for elimination. Impaired clearance of these negatively charged macromolecules by a dysfunctional endolymphatic sac will contribute to the chemical imbalance of endolymph which accompanies long-standing endolymphatic hydrops, and may be one of the reasons for the observed loss of function. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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