A controlled experimental model of revision implants: Part II. Implementation with loaded titanium implants and bone graft.
We used an experimental model producing an aggressive tissue response associated with implant loosening in humans: a 6 mm polymethylmethacrylate (PMMA) cylinder was pistoning 500 [mu]m concentrically in a 7.5 mm hole, with polyethylene (PE) particles, for 8 weeks. At 8 weeks, the PMMA implant was re...
| Publicado en: | Acta Orthopaedica Scandinavica Vol. 72; no. 6; pp. 650 - 657 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2001
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106096184&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106096184 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016470 1XH jtl: Acta Orthopaedica Scandinavica issn: 00016470 maglogo: Y pubinfo: dt: Dec2001 vid: 72 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106096184 2009444408 10.1080/000164701317269102 NLM11817883 106096184 ppf: 650 ppct: 7 formats: fmt: @attributes: type: P tig: atl: A controlled experimental model of revision implants: Part II. Implementation with loaded titanium implants and bone graft. aug: au: Bechtold JE Mouzin O Kidder L Søballe K sug: subj: Bone Transplantation Methods Joint Prosthesis Titanium Animal Studies Arthroplasty, Replacement, Knee Equipment and Supplies Arthroplasty, Replacement, Knee Methods Biocompatible Materials Dogs Joint Instability Prevention and Control Models, Biological Prosthesis Design Prosthesis Failure Range of Motion Reference Values Reoperation Sensitivity and Specificity ab: We used an experimental model producing an aggressive tissue response associated with implant loosening in humans: a 6 mm polymethylmethacrylate (PMMA) cylinder was pistoning 500 [mu]m concentrically in a 7.5 mm hole, with polyethylene (PE) particles, for 8 weeks. At 8 weeks, the PMMA implant was revised with a titanium alloy (Ti) implant, and an identical primary Ti implant was inserted contralaterally for 4 weeks. With this protocol, we evaluated primary and revision plasma-sprayed Ti implants which were loaded under stable conditions with or without allograft, or under unstable conditions without allograft (bilateral primary and revision implants, n 8 per group, 48 implants in 24 dogs). Revision implants had lower interfacial shear strength, less bone in contact with and adjacent to the implant, and resulted in higher levels of IL-6[beta] and TNF[alpha] and lower levels of TGF[beta]. In both the revision and primary settings, allograft increased shear strength, stiffness and energy, bone-implant contact, and bone area adjacent to the implant. Unstable implants could not generate a mechanically sound interface, and further exacerbated the difference between primary and revision. We conclude that factors important for improving the fixation of revision implants were bone graft and a stable interface. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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