Differential inhibition of human cancer cell proliferation by citrus limonoids.
Limonoids have been shown to inhibit the growth of estrogen receptor-negative and -positive human breast cancer cells in culture. The primary objective of this study was to test the antiproliferative activity of limonoids (obacunone 17[beta]-D-glucopyranoside, nomilinic acid 17[beta]-D-glucopyranosi...
| Publicado en: | Nutrition & Cancer Vol. 40; no. 2; pp. 180 - 185 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
2001
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106096370&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106096370 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2001 vid: 40 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106096370 2009444858 NLM11962254 106096370 ppf: 180 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Differential inhibition of human cancer cell proliferation by citrus limonoids. aug: au: Tian Q Miller EG Ahmad H Tang L Patil BS sug: subj: Cell Physiology Drug Effects Citrus Hydrocarbons Pharmacodynamics Hydrocarbons Neoplasms Pathology Apoptosis Drug Effects Benzopyrans Pharmacodynamics Breast Neoplasms Pathology Cells Cervix Neoplasms Pathology DNA Analysis Female Flow Cytometry Glycosides Pharmacodynamics Heterocyclic Compounds Pharmacodynamics Leukemia Pathology Liver Neoplasms Pathology Ovarian Neoplasms Pathology Plant Extracts Stomach Neoplasms Pathology Female ab: Limonoids have been shown to inhibit the growth of estrogen receptor-negative and -positive human breast cancer cells in culture. The primary objective of this study was to test the antiproliferative activity of limonoids (obacunone 17[beta]-D-glucopyranoside, nomilinic acid 17[beta]-D-glucopyranoside, limonin, nomilin, and a limonoid glucoside mixture), found in high concentrations in mandarin (Citrus reticulata Blanco), against a series of human cancer cell lines. The human cancer cell lines included leukemia (HL-60), ovary (SKOV-3), cervix (HeLa), stomach (NCI-SNU-1), liver (Hep G2), and breast (MCF-7). The growth-inhibitory effects of the four limonoids and the limonoid glucoside mixture against MCF-7 cells were significant, and the antiproliferative activity of the different citrus limonoids was also dose and time dependent. No significant effects were observed on growth of the other cancer cell lines treated with the four individual limonoids at 100 [mu]g/ml. At 100 ?g/ml, the limonoid glucoside mixture demonstrated a partial inhibitory effect on SKOV-3 cancer cells. With use of flow cytometry, it was found that all the limonoid samples could induce apoptosis in MCF-7 cells at relatively high concentrations (100 [mu]g/ml). Considering the high concentration needed to induce apoptosis, it is unlikely that this is the primary mechanism of action for the cytotoxic effects seen with limonoids in this study. Further work is needed in this area to establish the mechanism of action of citrus limonoids on human breast cancer cells. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|