A comparative study of growth-inhibitory effects of isoflavones and their metabolites on human breast and prostate cancer cell lines.
The possible growth-inhibitory properties of the recently synthesized novel metabolite 1-(2,4-dihydrobenzoyl)-1-(4-hydroxyphenyl)ethylene (2-de-O-DMA) and six other metabolites of isoflavones were investigated and compared with those of the major isoflavones genistein, daidzein, and glycitein on hum...
| Publicado en: | Nutrition & Cancer Vol. 42; no. 2; pp. 224 - 233 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Taylor & Francis Ltd
2002
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106098513&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106098513 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2002 vid: 42 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106098513 2009452588 NLM12416264 106098513 ppf: 224 ppct: 9 formats: fmt: @attributes: type: P tig: atl: A comparative study of growth-inhibitory effects of isoflavones and their metabolites on human breast and prostate cancer cell lines. aug: au: Xiang H Schevzov G Gunning P Williams HM Silink M sug: subj: Breast Neoplasms Drug Therapy Isoflavones Pharmacodynamics Prostatic Neoplasms Drug Therapy Apoptosis Drug Effects Breast Neoplasms Pathology Cell Physiology Drug Effects Cells Female Genistein Pharmacodynamics Isoflavones Metabolism Male Prostatic Neoplasms Pathology Female Male ab: The possible growth-inhibitory properties of the recently synthesized novel metabolite 1-(2,4-dihydrobenzoyl)-1-(4-hydroxyphenyl)ethylene (2-de-O-DMA) and six other metabolites of isoflavones were investigated and compared with those of the major isoflavones genistein, daidzein, and glycitein on human breast noncancer and breast and prostate cancer cell lines in vitro. The novel metabolite 2-de-O-DMA was found to be a more potent inhibitor than genistein on human breast cancer MCF-7, MDA-MB-468, and SK-BR-3 cells and breast noncancer MCF-10A cells. In prostate cancer cell lines, LNCaP and DU145, 2-de-O-DMA elicited a six- to sevenfold more potent inhibition than genistein. Flow cytometric analysis showed that 2-de-O-DMA and genistein blocked cells at the G[sub 2]/M phase of the cell cycle. Genistein and 2-de-O-DMA led to apoptosis of a variety of cancer cell lines. The rapid response of growth inhibition induced by 2-de-O-DMA compared with genistein strongly suggests that the observed antiproliferation effects elicited by this novel metabolite are mediated via a biological pathway different from that induced by genistein. 2-de-O-DMA, a novel metabolite of isoflavone, could have a potential role in chemopreventive and chemotherapeutic treatment of hormonal breast and prostate cancers. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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