Performance on a virtual reality spatial memory navigation task in depressed patients.
Objective: Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression.Method: Performance on a novel virtual reality navi...
| Publicado en: | American Journal of Psychiatry Vol. 164; no. 3; pp. 516 - 520 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
American Psychiatric Publishing, Inc.
Mar2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106120868&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106120868 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: Mar2007 vid: 164 iid: 3 pid: 37323 pub: American Psychiatric Publishing, Inc. place: Arlington, Virginia artinfo: ui: 106120868 106120868 NLM17329478 2009536291 10.1176/ajp.2007.164.3.516 NLM17329478 106120868 ppf: 516 ppct: 4 formats: tig: atl: Performance on a virtual reality spatial memory navigation task in depressed patients. aug: au: Gould NF Holmes MK Fantie BD Luckenbaugh DA Pine DS Gould TD Burgess N Manji HK Zarate CA Jr. Gould, Neda F Holmes, M Kathleen Fantie, Bryan D Luckenbaugh, David A Pine, Daniel S Gould, Todd D Burgess, Neil Manji, Husseini K Zarate, Carlos A Jr affil: Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Mark O. Hatfield Clinical Research Center, 10 Center Dr., Bethesda, MD 20892, USA sug: subj: Depression Diagnosis Memory Disorders Diagnosis Spatial Behavior User-Computer Interface Adult Bipolar Disorder Diagnosis Bipolar Disorder Psychosocial Factors Cognition Disorders Diagnosis Cognition Disorders Physiopathology Cognition Disorders Psychosocial Factors Depression Psychosocial Factors Descriptive Statistics Female Hippocampus Physiopathology Inpatients Intelligence Male Memory Memory Disorders Physiopathology Memory Disorders Psychosocial Factors Middle Age Outpatients P-Value Perception Phenotype Reproducibility of Results Scales Structured Interview T-Tests Task Performance and Analysis Test-Retest Reliability Human Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: Findings on spatial memory in depression have been inconsistent. A navigation task based on virtual reality may provide a more sensitive and consistent measure of the hippocampal-related spatial memory deficits associated with depression.Method: Performance on a novel virtual reality navigation task and a traditional measure of spatial memory was assessed in 30 depressed patients (unipolar and bipolar) and 19 normal comparison subjects.Results: Depressed patients performed significantly worse than comparison subjects on the virtual reality task, as assessed by the number of locations found in the virtual town. Between-group differences were not detected on the traditional measure. The navigation task showed high test-retest reliability.Conclusions: Depressed patients performed worse than healthy subjects on a novel spatial memory task. Virtual reality navigation may provide a consistent, sensitive measure of cognitive deficits in patients with affective disorders, representing a mechanism to study a putative endophenotype for hippocampal function. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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