Validation of automatically classified magnetic resonance images for carotid plaque compositional analysis.
Background and Purpose: MRI may be used for noninvasive assessment of atherosclerotic lesions; however, MRI evaluation of plaque composition requires validation against an accepted reference standard, such as the American Heart Association (AHA) lesion grade, defined by histopathological examination...
| Publicado en: | Stroke (00392499) Vol. 37; no. 1; pp. 93 - 98 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2006 Jan
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106127892&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106127892 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00392499 1FT jtl: Stroke (00392499) issn: 00392499 maglogo: N pubinfo: dt: 2006 Jan vid: 37 iid: 1 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106127892 106127892 NLM16339462 2009621790 10.1161/01.str.0000196985.38701.0c NLM16339462 106127892 ppf: 93 ppct: 5 formats: tig: atl: Validation of automatically classified magnetic resonance images for carotid plaque compositional analysis. aug: au: Clarke SE Beletsky V Hammond RR Hegele RA Rutt BK Clarke, Sharon E Beletsky, Vadim Hammond, Robert R Hegele, Robert A Rutt, Brian K affil: Imaging Research Laboratories, Robarts Research Institute, PO Box 5015, London, Ontario, Canada sug: subj: Carotid Artery Diseases Pathology Magnetic Resonance Imaging Methods Arteriosclerosis Brain Pathology Carotid Arteries Pathology Carotid Stenosis Contrast Media Endarterectomy Endarterectomy, Carotid Methods Funding Source Image Processing, Computer Assisted Intrarater Reliability Lipids Metabolism Paired T-Tests Probability Sensitivity and Specificity Tomography, X-Ray Computed Validation Studies Human ab: Background and Purpose: MRI may be used for noninvasive assessment of atherosclerotic lesions; however, MRI evaluation of plaque composition requires validation against an accepted reference standard, such as the American Heart Association (AHA) lesion grade, defined by histopathological examination.Methods: Forty-eight carotid endarterectomy specimen cross-sections had AHA lesion grade determined histopathologically and were concurrently imaged using combinations of 8 MRI contrast weightings in vitro. A maximum likelihood classification algorithm generated MRI "maps" of plaque components, and an AHA lesion grade was assigned correspondingly. Additional analyses compared classification accuracy obtained with a commonly used set of magnetic resonance contrast weightings [proton density (PDw), T1 (T1w), and partial T2 (T2w)] to accuracy obtained with the combination of PDw, T1w, and diffusion-weighted (Dw) contrast.Results: For the 8-contrast combination, the sensitivities for fibrous tissue, necrotic core, calcification, and hemorrhage detection were 83%, 67%, 86%, and 77%, respectively. The corresponding specificities were 81%, 78%, 99%, and 97%. Good agreement (79%) between magnetic resonance and histopathology for AHA classification was achieved. For the PDw, T1w, and Dw combination, the overall classification accuracy was insignificantly different at 78%, whereas the overall classification accuracy using PDw, T1w, and partial T2w contrast weightings was significantly lower at 67%.Conclusions: This study provides proof-of-principle that the composition of atherosclerotic plaques determined by automated classification of high-resolution ex vivo MRI accurately reflects lesion composition defined by histopathological examination. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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