Relationship between clinical features of Crohn's disease and the risk of developing extraintestinal manifestations.
OBJECTIVES: Crohn's disease is frequently associated with extraintestinal manifestations. The aim of this study was to evaluate the degree of association between the development of extraintestinal manifestations, the clinical forms of Crohn's disease according to the Vienna Classification and to the...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 19; no. 1; pp. 73 - 79 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
2007 Jan
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106133003&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106133003 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: 2007 Jan vid: 19 iid: 1 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106133003 106133003 2009504141 10.1097/01.meg.0000243883.47938.aa NLM17206080 106133003 ppf: 73 ppct: 6 formats: tig: atl: Relationship between clinical features of Crohn's disease and the risk of developing extraintestinal manifestations. aug: au: Barreiro-de Acosta M Domínguez-Muñoz JE Núñez-Pardo de Vera MC Lozano-León A Lorenzo A Peña S affil: Department of Gastroenterology, Vrije University Medical Centre, Amsterdam, the Netherlands. sug: subj: Crohn Disease Complications Crohn Disease Symptoms Adolescence Aged Arthritis Risk Factors Chi Square Test Confidence Intervals Crohn Disease Risk Factors Erythema Nodosum Risk Factors Female Fisher's Exact Test Genotype Interviews Male Multivariate Analysis Mutation Odds Ratio P-Value Pyoderma Gangrenosum Risk Factors Quality of Life Questionnaires Spain Spondylitis, Ankylosing Risk Factors Thrombosis Uveitis Human Adolescent: 13-18 years Aged: 65+ years Female Male ab: OBJECTIVES: Crohn's disease is frequently associated with extraintestinal manifestations. The aim of this study was to evaluate the degree of association between the development of extraintestinal manifestations, the clinical forms of Crohn's disease according to the Vienna Classification and to the presence of several potential risk factors of the disease. METHODS: One hundred and seventy-three consecutive Crohn's disease patients were studied. Sex, smoking habits, previous Crohn's disease-related surgery, family history of Crohn's disease, steroid dependency, steroid resistance and the presence of at least one mutant allele in any of the three considered variants of CARD15 gene were considered as potential risk factors. The Vienna Classification was applied, and the presence of extraintestinal manifestations was evaluated. RESULTS: A total of 61 (35.3%) patients developed extraintestinal manifestations. They were more frequently seen in women than in men (41.1 vs. 26.7%), (odds ratio 1.92, 95% confidence interval: 0.99-3.70; P=0.05) and in steroid-dependent patients than in steroid responders (61.1 vs. 28.5%), (odds ratio 3.94, 95% confidence interval: 1.83-8.49; P<0.01). No relationship was found in general between the extraintestinal manifestations of Crohn's disease and smoking habits, previous Crohn's disease-related surgery, a family history of Crohn's disease, steroid resistance and CARD15 mutations. Such relationships were, however, detected for some individual extraintestinal manifestations as between both smoking habits (odds ratio 9.09, 95% confidence interval: 1.15-71.66; P<0.05) and the G908R CARD15 mutation (odds ratio 4.76, 95% confidence interval: 1.11-20.43; P<0.05), respectively, and erythema nodosum. Patients with any colonic involvement of Crohn's disease (L2+L3) suffered from extraintestinal manifestations of the disease more frequently than patients without colonic involvement (42.7 vs. 25.9%, respectively; odds ratio 2.12, 95% confidence interval: 1.10-4.07; P<0.05). CONCLUSIONS: Female gender, steroid-dependency and colonic involvement are associated with the risk of developing extraintestinal manifestations of Crohn's disease. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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