Primary lymphoma of the nervous system.
This review article provides guidelines for the diagnosis, staging, and management of primary nervous system lymphoma based on the results of clinical trials conducted during the last decade. Recent progress in our understanding of the pathogenesis of primary nervous system lymphoma is summarized, a...
| Publicado en: | Cancer Journal Vol. 12; no. 1; pp. 1 - 14 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jan/Feb2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106175043&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106175043 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15289117 4U5 jtl: Cancer Journal issn: 15289117 maglogo: N pubinfo: dt: Jan/Feb2006 vid: 12 iid: 1 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106175043 NLM16613654 2009333304 10.1097/00130404-200601000-00001 NLM16613654 106175043 ppf: 1 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Primary lymphoma of the nervous system. aug: au: Baehring JM Hochberg FH Baehring, Joachim M Hochberg, Fred H affil: Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA sug: subj: Lymphoma, Non-Hodgkin's Diagnosis Lymphoma, Non-Hodgkin's Therapy Nervous System Neoplasms Diagnosis Nervous System Neoplasms Therapy Antimetabolites, Antineoplastic Therapeutic Use Combined Modality Therapy Eye Neoplasms Therapy Lymphoma, AIDS-Related Therapy Lymphoma, Non-Hodgkin's Epidemiology Lymphoma, Non-Hodgkin's Etiology Magnetic Resonance Imaging Methotrexate Therapeutic Use Nervous System Neoplasms Epidemiology Nervous System Neoplasms Etiology Organ Transplantation Radiotherapy Human ab: This review article provides guidelines for the diagnosis, staging, and management of primary nervous system lymphoma based on the results of clinical trials conducted during the last decade. Recent progress in our understanding of the pathogenesis of primary nervous system lymphoma is summarized, and implications of these findings for the development of diagnostic tools and new therapeutic strategies are outlined. We performed a search of the PubMed database (National Center for Biotechnology Information) for articles on primary nervous system lymphoma published between 1970 and May 2005. Primary nervous system lymphoma affects the brain, eye, and meninges as well as cranial, spinal, and peripheral nerves. Although important lessons have been learned from the pathogenesis of extraneural non-Hodgkin's lymphoma, the unique organotropism of primary nervous system lymphoma remains poorly understood. Diagnosis is facilitated by modern imaging techniques and molecular markers. Clinically recognizable "precursors" may exist but frequently elude specific diagnosis. Insight into the peculiar pharmacokinetics of chemotherapy aimed at tumors within the nervous system has led to the development of methotrexate-based regimens that can achieve prolonged progression-free survival without the use of radiation. Long-term survival and, in selected cases, even a cure are possible in primary nervous system lymphoma. Treatment should be provided in specialized multidisciplinary centers. In spite of remarkable progress through methotrexate-based chemotherapy, the majority of patients experience relapse within a few years. Better diagnostic tools are required for earlier diagnosis and monitoring of treatment response. A deeper understanding of the pathogenesis of primary nervous system lymphoma may reveal new therapeutic targets. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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