Indications, diagnostic tests and Helicobacter pylori eradication therapy. Recommendations by the 2nd Spanish Consensus Conference.

The results of the 2nd Spanish Consensus Conference for appropriate practice regarding indications for eradication, diagnostic tests, and therapy regimens for Helicobacter pylori infection are summarized. The Conference was based on literature searches in Medline, abstracts from three international...

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Published in:Spanish Journal of Gastroenterology / Revista Española de Enfermedades Digestivas Vol. 97; no. 5; pp. 348 - 375
Main Authors: Monés J, Gisbert JP, Borda F, Domínguez-Muñoz E
Format: research systematic review tables/charts Journal Article
Published: Aran Ediciones S.A. 2005 May
Online Access:View this record in EBSCOhost
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      pub: Aran Ediciones S.A.
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        atl: Indications, diagnostic tests and Helicobacter pylori eradication therapy. Recommendations by the 2nd Spanish Consensus Conference.
      aug:
        au:
          Monés J
          Gisbert JP
          Borda F
          Domínguez-Muñoz E
      sug:
        subj:
          Helicobacter Infections Prevention and Control
          Helicobacter Pylori Analysis
          Amoxicillin Administration and Dosage
          Antibiotic Prophylaxis Methods
          Clarithromycin Administration and Dosage
          Comorbidity Trends
          Congresses and Conferences
          Duodenal Ulcer Therapy
          Endoscopy, Gastrointestinal Methods
          Gastrointestinal Hemorrhage Therapy
          Helicobacter Infections Complications
          Helicobacter Infections Diagnosis
          Helicobacter Infections Drug Therapy
          Medical Practice, Evidence-Based
          Medline
          Outcomes (Health Care)
          Peptic Ulcer Therapy
          Practice Guidelines
          Proton Pump Inhibitors Administration and Dosage
          Spain
          Human
      ab: The results of the 2nd Spanish Consensus Conference for appropriate practice regarding indications for eradication, diagnostic tests, and therapy regimens for Helicobacter pylori infection are summarized. The Conference was based on literature searches in Medline, abstracts from three international meetings, and abstracts from national meetings. Results were agreed upon and approved by the whole group. Results are supplemented by evidence grades and recommendation levels according to the classification used in the Clinical Practice Guidelines issued by Cochrane Collaboration. Convincing indications (peptic ulcer, duodenal erosions with no history of ASA or NSAIDs, MALT lymphoma), and not so convincing indications (functional dyspepsia, patients receiving low-dose ASA for platelet aggregation, gastrectomy stump in patients operated on for gastric cancer, first-degree relatives of patients with gastric cancer, lymphocytic gastritis, and Ménétrier s disease) for H. pylori eradication are discussed. Diagnostic recommendations for various clinical conditions (peptic ulcer, digestive hemorrhage secondary to ulcer, eradication control, patients currently or recently receiving antibiotic or antisecretory therapy), as well as diagnostic tests requiring biopsy collection (histology, urease fast test, and culture) when endoscopy is needed for clinical diagnosis, and non-invasive tests requiring no biopsy collection (13C-urea breath test, serologic tests, and fecal antigen tests) when endoscopy is not needed are also discussed. As regards treatment, first-choice therapies (triple therapy using a PPI and two antibiotics), therapy length, quadruple therapy, and a number of novel antibiotic options as 'rescue' therapy are prioritized, the fact that prolonging PPI therapy following effective eradication is unnecessary for patients with duodenal ulcer but not for all gastric ulcers is documented, the fact that cultures and antibiograms are not needed for all eradicating therapies is indicated, and finally the test and treat strategy is considered adequate, however only under certain circumstances.
      pubtype: Periodical
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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