How do brain tumors alter functional connectivity? A magnetoencephalography study.
OBJECTIVE: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. METHODS: Functional connectivity was assessed by computing the synchronization likelihood in a broad band (0.5-60Hz) or in the g...
| Published in: | Annals of Neurology Vol. 59; no. 1; pp. 128 - 139 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jan2006
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106185119&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106185119 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03645134 1WM jtl: Annals of Neurology issn: 03645134 maglogo: Y pubinfo: dt: Jan2006 vid: 59 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 106185119 106185119 2009327059 10.1002/ana.20710 NLM16278872 106185119 ppf: 128 ppct: 11 formats: tig: atl: How do brain tumors alter functional connectivity? A magnetoencephalography study. aug: au: Bartolomei F Bosma I Klein M Baayen JC Reijneveld JC Postma TJ Heimans JJ van Dijk BW de Munck JC de Jongh A Cover KS Stam CJ affil: Department of Clinical Neurophysiology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands. fabrice.bartolomei@ap-hm.fr sug: subj: Brain Neoplasms Complications Brain Neoplasms Pathology Brain Neoplasms Physiopathology Diagnosis, Neurologic Nervous System Anatomy and Histology Nervous System Physiology Adult Aged Female Male Middle Age Seizures Etiology Seizures Physiopathology Human Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: OBJECTIVE: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. METHODS: Functional connectivity was assessed by computing the synchronization likelihood in a broad band (0.5-60Hz) or in the gamma band (30-60Hz) between all pairwise combinations of magnetoencephalography signals. Magnetoencephalography recordings were made at rest in 17 brain tumor patients and 15 healthy control subjects. For a given threshold of synchronization likelihood values, graphs of the suprathreshold connections between each magnetoencephalography channel and the others channels were built. RESULTS: In some regions, a variable number of channels without connectivity (missing connective points) at this threshold was found. The number of missing connective points was higher in patients with brain tumors than in control subjects (p < 0.0001, broad and gamma band) and was higher for left-sided than right-sided tumors (p = 0.008, broad band; p < 0.0001, gamma band). Individual results analysis indicates that the majority of brain tumor patients display several regions with missing connective point alterations in the affected and in the contralateral hemisphere. INTERPRETATION: Our findings suggest that brain tumors induce a loss of functional connectivity that affects multiple brain regions, and that left side brain tumors have the more severe consequences in this respect. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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