CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation.
Background: Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was...
| Publicado en: | Journal of Gastroenterology Vol. 41; no. 6; pp. 533 - 540 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106192943&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106192943 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: Jun2006 vid: 41 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 106192943 NLM16868800 2009248102 10.1007/s00535-006-1788-z NLM16868800 106192943 ppf: 533 ppct: 7 formats: tig: atl: CagA positivity and its association with gastroduodenal disease in Turkish children undergoing endoscopic investigation. aug: au: Sökücü S Özden AT Süoglu OD Elkabes B Demir F Cevikbas U Gökce S Saner G Sökücü, Semra Ozden, Ayşe Tülin Süoğlu, Ozlem Durmaz Elkabes, Berna Demir, Fikri Cevikbaş, Uğur Gökçe, Selim Saner, Günay affil: Department of Pediatric Gastroenterology and Hepatology, Istanbul School of Medicine, Istanbul University, Capa, 34390, Istanbul, Turkey sug: subj: Antibodies, Bacterial Blood Antigens, Bacterial Immunology Endoscopy, Gastrointestinal Gastrointestinal Diseases Blood Gastrointestinal Diseases Diagnosis Helicobacter Pylori Child Female Funding Source Gastrointestinal Diseases Epidemiology Helicobacter Infections Epidemiology Male Prospective Studies Turkiye Human Child: 6-12 years Female Male ab: Background: Cytotoxin-associated gene A (CagA) product is a bacterial virulence factor contributing to the pathogenicity of Helicobacter pylori (HP) infection in humans. Host factors, which vary in different countries, interact with bacterial factors to determine the disease state. Our objective was to investigate the frequency of CagA-positive HP strains and evaluate the contribution of CagA positivity to symptoms and development of mucosal lesions in HP-infected Turkish children.Methods: We conducted a prospective clinical trial in 240 consecutive Turkish children undergoing endoscopy (110 girls, 130 boys; mean age, 8.7 +/- 4.3 years). HP infection was diagnosed on the basis of a positive rapid urease test and histology of the mucosal specimens. HP IgG and CagA IgG antibodies were measured by enzyme-linked immunosorbent assay in HP-positive children.Results: The HP positivity rate was 50.4% in our study group (51 girls, 70 boys; mean age, 9.9 +/- 3.9 years). CagA was positive in 74.4%. HP infection was less common in children with vomiting (25.9%, P < 0.05). CagA positivity was not associated with any clinical symptom. HP positivity was higher in children with duodenal ulcer (80% vs. 49.1%, P = 0.05); while CagA positivity was similar. Antral nodularity was strongly associated with HP positivity and CagA positivity (30.6% vs. 3.4% and 36.7% vs. 12.9%, respectively, P < 0.05). A negative association between CagA positivity and esophagitis was observed (20% vs. 76.7%, P < 0.05).Conclusions: CagA positivity is common in HP-infected Turkish children. Esophageal lesions are less common in children infected with CagA-positive strains. Although HP is associated with duodenal ulcer disease, CagA positivity does not seem to contribute to development of ulcers in children in our series. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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