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Helicobacter pylori CagA status associated with gastric cancer incidence rate variability in Costa Rican regions.

Background: We evaluated several risk factors for gastric cancer in Costa Rican regions having contrasting gastric cancer incidence rates, despite the small dimensions of the country.Methods: A total of 180 dyspeptic patients were classified into two groups according to the gastric cancer incidence...

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Publicado en:Journal of Gastroenterology Vol. 41; no. 7; pp. 632 - 638
Autores principales: Con SA, Valerín AL, Takeuchi H, Con-Wong R, Con-Chin VG, Con-Chin GR, Yagi-Chaves SN, U. FM, Pino FB, Echandi G, Kobayashi M, Monge-Izaguirre M, Nishioka M, Morimoto N, Sugiura T, Araki K, Con, Sergio A, Valerín, Ana L, Takeuchi, Hiroaki, Con-Wong, Reinaldo
Formato: research tables/charts Journal Article
Publicado: Springer Nature Jul2006
Acceso en línea:Ver este registro en EBSCOhost
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        09441174
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      dt: Jul2006
      vid: 41
      iid: 7
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      pub: Springer Nature
      place: New York, New York
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        106195772
        NLM16932999
        2009274900
        10.1007/s00535-006-1812-3
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        atl: Helicobacter pylori CagA status associated with gastric cancer incidence rate variability in Costa Rican regions.
      aug:
        au:
          Con SA
          Valerín AL
          Takeuchi H
          Con-Wong R
          Con-Chin VG
          Con-Chin GR
          Yagi-Chaves SN
          U. FM
          Pino FB
          Echandi G
          Kobayashi M
          Monge-Izaguirre M
          Nishioka M
          Morimoto N
          Sugiura T
          Araki K
          Con, Sergio A
          Valerín, Ana L
          Takeuchi, Hiroaki
          Con-Wong, Reinaldo
        affil: Department of Tumor Surgery, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, 783-8505, Japan
      sug:
        subj:
          Antigens, Bacterial Metabolism
          Gastritis Epidemiology
          Helicobacter Infections Complications
          Helicobacter Pylori
          Proteins Metabolism
          Stomach Neoplasms Epidemiology
          Adult
          Aged
          Antibodies, Bacterial Blood
          Antigens, Bacterial
          Antigens, Bacterial Immunology
          Costa Rica
          Female
          Funding Source
          Gastritis Etiology
          Helicobacter Infections Epidemiology
          Helicobacter Infections Microbiology
          Helicobacter Pylori Metabolism
          Incidence
          Male
          Metaplasia
          Middle Age
          Proteins
          Proteins Immunology
          Stomach Neoplasms Etiology
          Human
          Adult: 19-44 years
          Aged: 65+ years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Background: We evaluated several risk factors for gastric cancer in Costa Rican regions having contrasting gastric cancer incidence rates, despite the small dimensions of the country.Methods: A total of 180 dyspeptic patients were classified into two groups according to the gastric cancer incidence (GCI) rate in their Costa Rican region: group A, with a high GCI rate (n = 91) and group B, with a low GCI rate (n = 89). Helicobacter pylori infection was detected by rapid urease test, Gram staining, and histological observation. Antral and corpus specimens were obtained to assess the grade of inflammation, topography of gastritis, gastric atrophy, and intestinal metaplasia by histological examination. Serum CagA antibody was measured by an antigen-specific enzyme-linked immunosorbent assay.Results: There was no significant difference in H. pylori prevalence between groups A (73%) and B (63%); however, serum CagA antibody was more frequently detected in group A (79%) than in group B (54%) [P = 0.02; odds ratio (OR), 2.68]. Among patients under 60 years of age, serum CagA antibody was even more frequently detected in group A (81%) than in group B (49%) (P < 0.01; OR, 4.50). The prevalence of corpus-predominant gastritis, atrophic gastritis, and moderate/severe grades of neutrophilic infiltration was higher in serum CagA antibody-positive patients than in CagA antibody-negative patients (P = 0.003, 0.04, and 0.002, respectively).Conclusions: Infection with H. pylori possessing the cagA gene is associated with the development of severe gastric damage such as gastric atrophy, leading to gastric cancer, and probably influences the differences in GCI between Costa Rican regions.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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