Experimental PVC material challenge in subjects with occupational PVC exposure.
BACKGROUND: Polyvinyl chloride (PVC) materials have been linked to asthma in several epidemiologic studies, but the possible causal factors remain unknown. PARTICIPANTS: We challenged 10 subjects experimentally to degraded PVC products under controlled conditions. All of the subjects had previously...
| Publicado en: | Environmental Health Perspectives Vol. 114; no. 9; pp. 1409 - 1414 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Sep2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106195847&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106195847 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Sep2006 vid: 114 iid: 9 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 106195847 106195847 2009290657 10.1289/ehp.8965 NLM16966097 106195847 ppf: 1409 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Experimental PVC material challenge in subjects with occupational PVC exposure. aug: au: Tuomainen A Stark H Seuri M Hirvonen M Linnainmaa M Sieppi A Tukiainen H affil: Technology Centre Teknia Ltd., P.O. Box 1188, FIN-70211 Kuopio, Finland; anneli.tuomainen@teknia.fi sug: subj: Asthma Chemically Induced Environmental Monitoring Lung Drug Effects Occupational Diseases Etiology Premature Ventricular Contractions Adult Alcohols Asthma Diagnosis Asthma Epidemiology Body Fluids Immunology Breath Tests Chi Square Test Cytokines Analysis Cytokines Metabolism Data Analysis Software Environmental Exposure Fisher's Exact Test Funding Source Lung Pathology Middle Age Nitric Oxide Analysis Nitric Oxide Metabolism Occupational Diseases Diagnosis Occupational Diseases Epidemiology Occupational Exposure Pearson's Correlation Coefficient Human Adult: 19-44 years Middle Aged: 45-64 years ab: BACKGROUND: Polyvinyl chloride (PVC) materials have been linked to asthma in several epidemiologic studies, but the possible causal factors remain unknown. PARTICIPANTS: We challenged 10 subjects experimentally to degraded PVC products under controlled conditions. All of the subjects had previously experienced respiratory symptoms suspected to be caused by this kind of exposure in their work place. Five subjects had doctor-diagnosed asthma. METHODS: The subjects were exposed to degraded PVC material in an exposure chamber ; a challenge with ceramic tile was used as the control test. We followed exhaled nitric oxide, nasal NO, lung functions, cytokines [tumor necrosis factor-alpha (TNF-alpha) , interleukin-4 (IL-4) , IL-6, and IL-12] and NO in nasal lavage fluid (NAL) during and after the exposures. We also measured 2-ethylhexanol in exhaled breath samples and NAL. RESULTS: On the morning after the PVC exposure, subjects reported respiratory tract symptoms significantly more often than they did after the control test (50% vs. 0%, respectively ; p = 0.029 ; n = 10) . We did not detect any changes in lung functions or levels of exhaled NO, nasal NO, or NO in NAL after PVC challenge compared with the control test. Cytokine levels increased after both exposures, with no statistically significant difference between situations. All of the exhaled breath samples collected during the PVC exposure contained 2-ethylhexanol. CONCLUSIONS: PVC flooring challenge can evoke respiratory tract symptoms in exposed subjects. Our results do not support the hypothesis that PVC materials themselves evoke immediate asthmatic reactions. The chamber test used is well suited to this type of exposure study. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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