Experimentally induced acute sinusitis and efficacy of vitamin A.
Conclusions. Although antibiotics are the mainstays for treatment of sinusitis, they do not specifically treat tissue damage due to free radicals. We propose that antioxidant, anti-infective, immunomodulator vitamin A may be a useful addition in the management of sinusitis. Objectives. Acute sinusit...
| Publicado en: | Acta Oto-Laryngologica Vol. 127; no. 8; pp. 855 - 861 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Aug2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106196281&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106196281 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Aug2007 vid: 127 iid: 8 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106196281 2009660839 10.1080/00016480601053107 NLM17762998 106196281 ppf: 855 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Experimentally induced acute sinusitis and efficacy of vitamin A. aug: au: Guven M Aladag I Eyibilen A Filiz NO Ozyurt H Yelken K affil: Department of ORL, Gaziosmanpasa University, Tokat, Turkey. sug: subj: Sinusitis Drug Therapy Streptococcal Infections Drug Therapy Vitamin A Therapeutic Use Administration, Oral Animal Studies Antibiotics Administration and Dosage Antibiotics Therapeutic Use Descriptive Statistics Drug Therapy, Combination Kruskal-Wallis Test Malondialdehyde Metabolism Mann-Whitney U Test Mucous Membrane Metabolism Mucous Membrane Microbiology Mucous Membrane Pathology Nitric Oxide Metabolism One-Way Analysis of Variance Oxidoreductases Metabolism Post Hoc Analysis Prospective Studies Rabbits Sinusitis Metabolism Sinusitis Microbiology Spectrophotometry Streptococcal Infections Microbiology Streptococcal Infections Pathology Superoxide Dismutase Metabolism Treatment Outcomes Vitamin A Administration and Dosage ab: Conclusions. Although antibiotics are the mainstays for treatment of sinusitis, they do not specifically treat tissue damage due to free radicals. We propose that antioxidant, anti-infective, immunomodulator vitamin A may be a useful addition in the management of sinusitis. Objectives. Acute sinusitis is one of the most common diseases in humans. Vitamin A is a fat-soluble vitamin and essential for immunity, cellular differentiation, and maintenance of respiratory and gastrointestinal epithelial surfaces, growth, reproduction, and vision. The objective of this study was to investigate the therapeutic role of vitamin A on healing of acute sinusitis. Materials and methods. This was a prospective controlled animal trial. Experimental sinusitis was induced by blocking the right nose and inoculating Streptococcus pneumoniae into the right maxillary sinuses. Left maxillary sinuses were used as controls. Rabbits were divided in to two groups. At 48h after inoculation, group I received only parenteral ampicillin-sulbactam (50mg/kg), group II was treated with parenteral ampicillin-sulbactam (50mg/kg) and parenteral a dose of 100000 IU vitamin A in palmitate form. All animals were sacrificed on the 10th day. Mucosal samples were excised from the infected and control sinuses for histopathologic examination, for measurement of activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), and for evaluation of levels of malondialdehyde (MDA) and nitric oxide (NO). Results. All the infected sinuses displayed signs of inflammation, but there was no statistically significant difference between the study and control groups. In our study, epithelial integrity as well as NO and MDA levels were better in the group receiving both antibiotic and vitamin A than the group receiving antibiotic alone. Nevertheless, SOD activity was significantly increased in the group receiving only antibiotics, compared with the control mucosal SOD activity. There was no difference between the groups as regards CAT and GSH activity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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