Velopharyngeal anatomy in 22q11.2 deletion syndrome: a three-dimensional cephalometric analysis.
Objective: 22q11.2 deletion syndrome is the most common genetic cause of velopharyngeal dysfunction (VPD). Magnetic resonance imaging (MRI) is a promising method for noninvasive, three-dimensional (3D) assessment of velopharyngeal (VP) anatomy. The purpose of this study was to assess VP structure in...
| Publicado en: | Cleft Palate Craniofacial Journal Vol. 43; no. 4; pp. 446 - 457 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jul2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106247752&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106247752 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10556656 DF1 jtl: Cleft Palate Craniofacial Journal issn: 10556656 maglogo: Y pubinfo: dt: Jul2006 vid: 43 iid: 4 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 106247752 106247752 2009242941 10.1597/04-193.1 NLM16854203 106247752 ppf: 446 ppct: 11 formats: tig: atl: Velopharyngeal anatomy in 22q11.2 deletion syndrome: a three-dimensional cephalometric analysis. aug: au: Ruotolo RA Veitia NA Corbin A McDonough J Solot CB McDonald-McGinn D Zackai EH Emanuel BS Cnaan A LaRossa D Arens R Kirschner RE affil: Plastic Surgery Resident, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania sug: subj: Chromosome Disorders Pathology Chromosomes Mutation Palate, Soft Pathology Adenoids Pathology Case Control Studies Cephalometry Child Child, Preschool Chromosome Disorders Complications Descriptive Statistics Female Magnetic Resonance Imaging Male Pharynx Pathology Retrospective Design Sample Size Skull Abnormalities Syndrome T-Tests Tonsil Pathology Two-Tailed Test Wilcoxon Rank Sum Test Human Child: 6-12 years Child, Preschool: 2-5 years Female Male ab: Objective: 22q11.2 deletion syndrome is the most common genetic cause of velopharyngeal dysfunction (VPD). Magnetic resonance imaging (MRI) is a promising method for noninvasive, three-dimensional (3D) assessment of velopharyngeal (VP) anatomy. The purpose of this study was to assess VP structure in patients with 22q11.2 deletion syndrome by using 3D MRI analysis. Design: This was a retrospective analysis of magnetic resonance images obtained in patients with VPD associated with a 22q11.2 deletion compared with a normal control group. Setting: This study was conducted at The Children's Hospital of Philadelphia, a pediatric tertiary care center. Patients, Participants: The study group consisted of 5 children between the ages of 2.9 and 7.9 years, with 22q11.2 deletion syndrome confirmed by fluorescence in situ hybridization analysis. All had VPD confirmed by nasendoscopy or videofluoroscopy. The control population consisted of 123 unaffected patients who underwent MRI for reasons other than VP assessment. Interventions: Axial and sagittal Ti- and T2-weighted magnetic resonance images with 3-mm slice thickness were obtained from the orbit to the larynx in all patients by using a 1.5T Siemens Visions system. Outcome Measures: Linear, angular, and volumetric measurements of VP structures were obtained from the magnetic resonance images with VIDA image-processing software. Results: The study group demonstrated greater anterior and posterior cranial base and atlanto-dental angles. They also demonstrated greater pharyngeal cavity volume and width and lesser tonsillar and adenoid volumes. Conclusion: Patients with a 22q11.2 deletion demonstrate significant alterations in VP anatomy that may contribute to VPD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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