Genotype-by-nutrient interactions assessed in European obese women: a case-only study.
BACKGROUND: The development of obesity is influenced by both genetic and environmental risk factors. Whereas changes in the environment appear to be responsible for the increasing prevalence of obesity, genetic factors interacting with environmental factors would contribute to explain obesity onset...
| Publicado en: | European Journal of Nutrition Vol. 45; no. 8; pp. 454 - 463 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106262326&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106262326 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2006 vid: 45 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 106262326 106262326 2009480611 10.1007/s00394-006-0619-6 NLM17080261 106262326 ppf: 454 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Genotype-by-nutrient interactions assessed in European obese women: a case-only study. aug: au: Santos JL Boutin P Verdich C Holst C Larsen LH Toubro S Dina C Saris WHM Blaak EE Hoffstedt J Taylor MA Polak J Clement K Langin D Astrup A Froguel P Pedersen O Sorensen TIA Martinez JA affil: Dept. of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Spain, jalfmtz@unav.es. sug: subj: Dietary Fats Genotype Obesity Women Adipocytes Adult Appetite Chi Square Test Confidence Intervals Cross Sectional Studies Data Analysis Software Descriptive Statistics Diet Records Europe Exploratory Research Female Funding Source Genes Genetic Techniques Glucose Metabolism Lipids Metabolism Middle Age Nutrients Obesity Familial and Genetic Odds Ratio Pearson's Correlation Coefficient Polymorphism, Genetic Human Adult: 19-44 years Middle Aged: 45-64 years Female ab: BACKGROUND: The development of obesity is influenced by both genetic and environmental risk factors. Whereas changes in the environment appear to be responsible for the increasing prevalence of obesity, genetic factors interacting with environmental factors would contribute to explain obesity onset and severity. AIM: To explore epidemiologic genotype-by-nutrient interactions in obesity. METHODS: A total of 42 polymorphisms of 26 candidate genes for obesity were genotyped in 549 adult obese women recruited from eight European centres in a case-only study. The nutritional variables assessed in this study were the dietary fibre intake (grams per day), the ratio of dietary polyunsaturated fat to saturated fat (P:S ratio) and the percentage of energy derived from fat in the diet as calculated from a weighed three-day food record (%E). Under the assumption of genotype-nutrient independence in the population, the odds ratio calculated in a sample of obese women would indicate the existence of genotype-by-nutrient interactions, measured as deviations from the multiplicative effects of the genetic and the nutrient factors separately. RESULTS: No new but confirmaty evidences for genotype-by-nutrient interactions in obesity were detected in this case-only study. The test of interaction between fibre intake and the -514 C > T polymorphism of the hepatic lipase gene (LIPC) yielded P-values of 0.01 across different statistical models. Likewise, the -11377G > C polymorphism of the adiponectin gene (ADIPOQ) and the -681 C > G polymorphism of the PPARG3 gene might interact with the percentage of energy derived from fat in the diet for the development of obesity (P-values in the range of 0.01-0.05 across different statistical models). The P-values were not adjusted for multiple testing, so these results should be considered with caution. CONCLUSIONS: Although the use of obese-only samples is theoretically a useful approach to detect interactions, few genotype-by-nutrient interactions have been suggested in obese European women after the analysis of candidate polymorphisms and the selected nutrient variables. The most remarkable multiplicative interaction found in this study refers to the combination of the hepatic lipase gene polymorphism -514 C > T and fibre intake. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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