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Bisphosphonate-associated osteonecrosis of the jaw: a literature review and clinical practice guidelines.

Background. Osteonecrosis of the jaw has recently been reported as a possible adverse drug effect from bisphosphonate therapy. Reports are coming from all over the world. Norvartis, a pharmaceutical manufacturer of two implicated drug products, has notified dentists in the United States and made rec...

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Published in:Journal of Dental Hygiene Vol. 80; no. 3; pp. 12p - 13
Main Author: Pickett FA
Format: pictorial practice guidelines review Journal Article
Published: American Dental Hygienists Association Summer2006
Online Access:View this record in EBSCOhost
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      dt: Summer2006
      vid: 80
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      pub: American Dental Hygienists Association
      place: Chicago, Illinois
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        atl: Bisphosphonate-associated osteonecrosis of the jaw: a literature review and clinical practice guidelines.
      aug:
        au: Pickett FA
        affil: Adjunct Associate Professor, East Tennessee State University, Dental Hygiene Program; fpickett@preferred.com
      sug:
        subj:
          Diphosphonates Adverse Effects
          Jaw Diseases Chemically Induced
          Osteonecrosis Chemically Induced
          Bone and Bones Blood Supply
          Bone Remodeling Drug Effects
          Jaw Diseases Physiopathology
          Jaw Diseases Prevention and Control
          Osteonecrosis Physiopathology
          Osteonecrosis Prevention and Control
          Tooth Extraction Adverse Effects
          United States
      ab: Background. Osteonecrosis of the jaw has recently been reported as a possible adverse drug effect from bisphosphonate therapy. Reports are coming from all over the world. Norvartis, a pharmaceutical manufacturer of two implicated drug products, has notified dentists in the United States and made recommendations for dental management of cases. Mechanism of Action. The exact mechanism of bisphosphonate effects leading to osteonecrosis of the jaw is unknown. The condition can affect both the maxilla and the mandible. Most cases developed following oral infection or dental treatment. Prevention and Management. Clinical guidelines for prevention and management have recently been published. Dental hygienists have a major role in patient education related to awareness of the potential drug effect and to preventive oral health education.
      pubtype: Academic Journal
      doctype:
        pictorial
        practice guidelines
        review
        Journal Article
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    language: English
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