Usefulness of temazepam and zaleplon to induce afternoon sleep.
Unlabelled: Insufficient daytime sleep may result in reduction of effectiveness and safety during overnight military missions. The usefulness of temazepam and zaleplon to optimize afternoon sleep and their effects on performance and alertness during a subsequent night shift were studied.Method: In a...
| Publicado en: | Military Medicine Vol. 171; no. 10; pp. 998 - 1002 |
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| Autores principales: | , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Oct2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106277087&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106277087 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00264075 4DV jtl: Military Medicine issn: 00264075 maglogo: N pubinfo: dt: Oct2006 vid: 171 iid: 10 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106277087 106277087 NLM17076453 2009311149 10.7205/milmed.171.10.998 NLM17076453 106277087 ppf: 998 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Usefulness of temazepam and zaleplon to induce afternoon sleep. aug: au: Simons R Koerhuis CL Valk PJL Van den Oord HAH Simons, Ries Koerhuis, Claudy L Valk, Pierre J L Van den Oord, Marieke H A H affil: TNO Human Factors, Aerospace Medicine Group, P.O. Box 23, 3769 ZG Soesterberg, The Netherlands sug: subj: Antianxiety Agents, Benzodiazepine Pharmacodynamics Heterocyclic Compounds Pharmacodynamics Hypnotics and Sedatives Pharmacodynamics Military Personnel Psychosocial Factors Sleep Deprivation Drug Therapy Sleep Drug Effects Adult Attention Clinical Assessment Tools Cognition Crossover Design Descriptive Statistics Double-Blind Studies Funding Source Male Pearson's Correlation Coefficient Repeated Measures Safety T-Tests Time Factors Treatment Outcomes Wakefulness Drug Effects Human Adult: 19-44 years Male ab: Unlabelled: Insufficient daytime sleep may result in reduction of effectiveness and safety during overnight military missions. The usefulness of temazepam and zaleplon to optimize afternoon sleep and their effects on performance and alertness during a subsequent night shift were studied.Method: In a randomized double-blind within-subjects design, 11 subjects took 20 mg of temazepam, 10 mg of zaleplon, or placebo before a 5:30-10:00 p.m. sleep period. Sleep length and quality were measured. Subjects were kept awake throughout the night while alertness, cognitive performance, and muscle power were repeatedly measured.Results: Temazepam provided significantly longer and qualitatively better sleep than zaleplon or placebo. During the night, sleepiness increased and muscle power was impaired in all conditions. Better sleep was correlated with less sleepiness during the night.Conclusion: Temazepam is useful to optimize a 4.5-hour afternoon sleep before overnight missions. Irrespective of hypnotic treatment, sleepiness and fatigue increased during the night shift. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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