Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment.
Background: Magnetic resonance diffusion tensor imaging (DTI) shows promise in the early detection of microstructural pathophysiological changes in the brain.Objectives: To measure microstructural differences in the brains of participants with amnestic mild cognitive impairment (MCI) compared with a...
| Publicado en: | Journal of Neurology, Neurosurgery & Psychiatry Vol. 77; no. 10; pp. 1122 - 1129 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | clinical trial diagnostic images research tables/charts Journal Article |
| Publicado: |
BMJ Publishing Group
Oct2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106278039&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106278039 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00223050 1Z1 jtl: Journal of Neurology, Neurosurgery & Psychiatry issn: 00223050 maglogo: N pubinfo: dt: Oct2006 vid: 77 iid: 10 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 106278039 NLM16754694 2009500175 10.1136/jnnp.2005.074336 NLM16754694 PMC2077533 106278039 ppf: 1122 ppct: 7 formats: tig: atl: Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment. aug: au: Rose SE McMahon KL Janke AL O'Dowd B de Zubicaray G Strudwick MW Chalk JB Rose, S E McMahon, K L Janke, A L O'Dowd, B de Zubicaray, G Strudwick, M W Chalk, J B affil: Centre for Magnetic Resonance, University of Queensland, Brisbane 4072, Australia sug: subj: Amnesia Pathology Brain Pathology Cognition Disorders Magnetic Resonance Imaging Aged Aged, 80 and Over Alzheimer's Disease Diagnosis Alzheimer's Disease Pathology Amnesia Psychosocial Factors Clinical Trials Cognition Disorders Psychosocial Factors Comparative Studies Descriptive Statistics Female Funding Source Male Neuropsychological Tests Optics P-Value Scales Human Aged: 65+ years Aged, 80 & over Female Male ab: Background: Magnetic resonance diffusion tensor imaging (DTI) shows promise in the early detection of microstructural pathophysiological changes in the brain.Objectives: To measure microstructural differences in the brains of participants with amnestic mild cognitive impairment (MCI) compared with an age-matched control group using an optimised DTI technique with fully automated image analysis tools and to investigate the correlation between diffusivity measurements and neuropsychological performance scores across groups.Methods: 34 participants (17 participants with MCI, 17 healthy elderly adults) underwent magnetic resonance imaging (MRI)-based DTI. To control for the effects of anatomical variation, diffusion images of all participants were registered to standard anatomical space. Significant statistical differences in diffusivity measurements between the two groups were determined on a pixel-by-pixel basis using gaussian random field theory.Results: Significantly raised mean diffusivity measurements (p<0.001) were observed in the left and right entorhinal cortices (BA28), posterior occipital-parietal cortex (BA18 and BA19), right parietal supramarginal gyrus (BA40) and right frontal precentral gyri (BA4 and BA6) in participants with MCI. With respect to fractional anisotropy, participants with MCI had significantly reduced measurements (p<0.001) in the limbic parahippocampal subgyral white matter, right thalamus and left posterior cingulate. Pearson's correlation coefficients calculated across all participants showed significant correlations between neuropsychological assessment scores and regional measurements of mean diffusivity and fractional anisotropy.Conclusions: DTI-based diffusivity measures may offer a sensitive method of detecting subtle microstructural brain changes associated with preclinical Alzheimer's disease. pubtype: Academic Journal doctype: clinical trial diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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