Group A streptococcal infections of the skin: molecular advances but limited therapeutic progress.
PURPOSE OF REVIEW: With the sequencing of several Streptococcus pyogenes (group A Streptococcus) genomes have come major advances in understanding the pathogenesis of group A Streptococcus-associated diseases. This review focuses on group A Streptococcus skin infections and summarizes data published...
| Publicado en: | Current Opinion in Infectious Diseases Vol. 19; no. 2; pp. 132 - 139 |
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| Autor principal: | |
| Formato: | review Journal Article |
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Lippincott Williams & Wilkins
Apr2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106279956&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106279956 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09517375 IQU jtl: Current Opinion in Infectious Diseases issn: 09517375 maglogo: N pubinfo: dt: Apr2006 vid: 19 iid: 2 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106279956 106279956 2009333750 10.1097/01.qco.0000216623.82950.11 NLM16514337 106279956 ppf: 132 ppct: 7 formats: tig: atl: Group A streptococcal infections of the skin: molecular advances but limited therapeutic progress. aug: au: Currie BJ affil: Tropical and Emerging Infectious Diseases Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory 0811, Australia. bart@menzies.edu.au sug: subj: Bacterial Infections Drug Therapy Bacterial Infections Microbiology Bacterial Infections Prevention and Control Bacterial Vaccines Skin Diseases, Infectious Drug Therapy Skin Diseases, Infectious Microbiology Skin Diseases, Infectious Prevention and Control Streptococcal Infections Drug Therapy Streptococcal Infections Microbiology Streptococcal Infections Prevention and Control Streptococcus Streptococcus Classification Virulence ab: PURPOSE OF REVIEW: With the sequencing of several Streptococcus pyogenes (group A Streptococcus) genomes have come major advances in understanding the pathogenesis of group A Streptococcus-associated diseases. This review focuses on group A Streptococcus skin infections and summarizes data published in the English language medical literature in 2004 and 2005. RECENT FINDINGS: Group A Streptococcus shows enormous and evolving molecular diversity driven by horizontal transmission between group A Streptococcus strains and between group A Streptococcus and other streptococci. Acquisition of prophages accounts for much of the diversity, conferring both virulence through phage-associated virulence factors and increased bacterial survival against host defences. Studies of group A Streptococcus isolates outside the US also question the generalizability of classic group A Streptococcus M serotype associations with specific disease entities such as acute rheumatic fever and necrotizing fasciitis. The distinction between throat and skin group A Streptococcus has become blurred. Although there have been few advances in treatment of group A Streptococcus skin infections, developments towards group A Streptococcus vaccines are promising. SUMMARY: The diversity of group A Streptococcus remains a challenge for vaccine development. As acute rheumatic fever and streptococcal pyoderma occur predominantly in disadvantaged populations, international funding support will be necessary for any group A Streptococcus vaccine to have a sustained impact on the global burden of disease. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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