Long-term habituation of the smile response with deep brain stimulation.
Human and animal research has shown that the ventral striatum, including the nucleus accumbens, may play a critical role in mediating positive emotions. Recently we described a subject with obsessive-compulsive disorder who intra-operatively exhibited the acute onset of an asymmetric smile and acute...
| Publicado en: | Neurocase (Taylor & Francis Ltd) Vol. 12; no. 3; pp. 191 - 197 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | case study diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jun2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106284525&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106284525 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13554794 1II8 jtl: Neurocase (Taylor & Francis Ltd) issn: 13554794 maglogo: N pubinfo: dt: Jun2006 vid: 12 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106284525 NLM16801154 2009233428 10.1080/13554790600646995 NLM16801154 106284525 ppf: 191 ppct: 6 formats: tig: atl: Long-term habituation of the smile response with deep brain stimulation. aug: au: Springer US Bowers D Goodman WK Shapira NA Foote KD Okun MS Springer, Utaka S Bowers, Dawn Goodman, Wayne K Shapira, Nathan A Foote, Kelly D Okun, Michael S affil: Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainsville, Florida 32610-0165, USA sug: subj: Facial Expression Evaluation Habits Obsessive-Compulsive Disorder Surgery Physical Stimulation Adverse Effects Adult Electrodes, Implanted Emotions Evaluation Female Funding Source Hamilton Rating Scale for Depression Motion Analysis Systems One-Shot Case Study Postoperative Complications Postoperative Period Psychological Tests Scales Time Factors Human Adult: 19-44 years Female ab: Human and animal research has shown that the ventral striatum, including the nucleus accumbens, may play a critical role in mediating positive emotions. Recently we described a subject with obsessive-compulsive disorder who intra-operatively exhibited the acute onset of an asymmetric smile and acute positive emotional change with contralateral deep brain stimulation (DBS) in either the right or left nucleus accumbens and anterior limb of the internal capsule region. The purpose of the present study was to examine the stability of the stimulation-induced smile(s) over a 12-month period. Custom computer software objectively quantified left and right facial movement during DBS. Although stimulation-induced smiles were elicited at one and two months post-surgery, they were no longer present from 3-12 months following chronic high frequency DBS. The smiles could not be elicited even with long washout periods. These findings imply potential long-term habituation and changes in the neural chemistry (possibly neuroplasticity) induced by chronic DBS. pubtype: Academic Journal doctype: case study diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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