Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever.
Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF. Acute DHF was defined by an abundance of transcripts from cell cycle- and endoplasmic reticulu...
| Publicado en: | Journal of Infectious Diseases Vol. 195; no. 8; pp. 1097 - 1108 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
4/15/2007
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106291686&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106291686 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00221899 1YU jtl: Journal of Infectious Diseases issn: 00221899 maglogo: N pubinfo: dt: 4/15/2007 vid: 195 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106291686 NLM17357045 2009552709 10.1086/512162 NLM17357045 PMC4042601 106291686 ppf: 1097 ppct: 11 formats: tig: atl: Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. aug: au: Simmons CP Popper S Dolocek C Chau TN Griffiths M Dung NTP Long TH Hoang DM Chau NV Thao LTT Hien TT Relman DA Farrar J Simmons, Cameron P Popper, Stephen Dolocek, Christiane Chau, Tran Nguyen Bich Griffiths, Michael Dung, Nguyen Thi Phuong Long, Truong Hoang affil: Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam sug: subj: Dengue Familial and Genetic Gene Expression Genome Adult B Lymphocytes Biochips Cytokines Cytokines Analysis Dengue Complications Dengue Diagnosis Dengue Immunology Dengue Physiopathology DNA Analysis Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Funding Source Male Pearson's Correlation Coefficient Polymerase Chain Reaction Post Hoc Analysis RNA Analysis Vietnam Human Adult: 19-44 years Female Male ab: Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF. Acute DHF was defined by an abundance of transcripts from cell cycle- and endoplasmic reticulum (ER)-related genes, suggesting a proliferative response accompanied by ER stress. Transcript-abundance levels for immunoresponse-associated genes, including cell surface markers, immunoglobulin, and innate response elements, were also elevated. Twenty-four genes were identified for which transcript abundance distinguished patients with dengue shock syndrome (DSS) from those without DSS. All the gene transcripts associated with DSS, many of which are induced by type I interferons, were less abundant in patients with DSS than in those without DSS. To our knowledge, these data provide the first snapshot of gene-expression patterns in peripheral blood during acute dengue and suggest that DSS is associated with attenuation of selected aspects of the innate host response. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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