Effect of a tomato drink intervention on insulin-like growth factor (IGF)-1 serum levels in healthy subjects.
There is concern that dietary factors can modulate the insulin-like growth factor (IGF) system. The aim of this work was to evaluate the effect of a tomato drink intervention providing small amounts of lycopene and other carotenoids on serum levels of IGF-1. Twenty healthy young subjects participate...
| Publicado en: | Nutrition & Cancer Vol. 55; no. 2; pp. 157 - 163 |
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| Autores principales: | , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106294385&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106294385 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: 2006 vid: 55 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106294385 106294385 2009346250 10.1207/s15327914nc5502_6 NLM17044770 106294385 ppf: 157 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Effect of a tomato drink intervention on insulin-like growth factor (IGF)-1 serum levels in healthy subjects. aug: au: Riso P Brusamolino A Martinetti A Porrini M affil: Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, 20133 Milan, Italy sug: subj: Antioxidants Pharmacodynamics Beverages Carotenoids Pharmacodynamics Somatomedins Drug Effects Somatomedins Metabolism Tomatoes Analysis Adult Analysis of Variance Antioxidants Metabolism beta Carotene Blood beta Carotene Pharmacodynamics Carotenoids Blood Chromatographs Crossover Design Data Analysis Software Double-Blind Studies Female Funding Source Male Regression Repeated Measures Human Adult: 19-44 years Female Male ab: There is concern that dietary factors can modulate the insulin-like growth factor (IGF) system. The aim of this work was to evaluate the effect of a tomato drink intervention providing small amounts of lycopene and other carotenoids on serum levels of IGF-1. Twenty healthy young subjects participated in a repeated measure double-blind, cross-over design. Subjects consumed 250 ml of a tomato drink or a placebo drink for 26 days separated by 26 days wash-out. The tomato drink intake increased plasma lycopene, phytoene, phytofluene, and [beta]-carotene concentrations by 0.22, 0.12, 0.13, and 0.18 [mu]mol/L, respectively (P < 0.05). No significant effect of the tomato drink intake on IGF-1 levels was observed. However, changes in lycopene before and after each experimental period were inversely and significantly correlated with those of IGF-1 (r = -0.33, P < 0.05, N = 20). No correlation was found with the other carotenoids. A significant reduction of IGF-1 serum level (-5.7%) was observed in subjects (n = 11) with the highest plasma lycopene response but also IGF-1 levels following the tomato drink intake (P < 0.05). No effect was evident after the placebo treatment. The results suggest that further exploration of the role of tomato lycopene on IGF-1 modulation both on healthy and on subjects at risk is necessary. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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