Accuracy of CO2 conductance predicted using a morphometric model of the middle ear mucosa.
Conclusion. These results hold promise that morphometric analysis can be used to generate transMEM (middle ear mucosa) gas conductance estimates for MEM geometries representative of the shift from healthy to pathologic states (e.g. increased MEM thickness and capillary density). Objectives. Novel st...
| Publicado en: | Acta Oto-Laryngologica Vol. 126; no. 12; pp. 1252 - 1260 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2006
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106298866&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106298866 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Dec2006 vid: 126 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 106298866 2009342535 10.1080/00016480600794420 NLM17101585 106298866 ppf: 1252 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Accuracy of CO2 conductance predicted using a morphometric model of the middle ear mucosa. aug: au: Kanick SC Kasi S Swarts JD Banks J Yuksel S Doyle WJ affil: Division of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA. sug: subj: Carbon Dioxide Metabolism Ear, Middle Anatomy and Histology Animal Studies Descriptive Statistics Diffusion Ear, Middle Metabolism Funding Source Image Processing, Computer Assisted Mucous Membrane Metabolism Mucous Membrane Physiology Partial Pressure Rodents ab: Conclusion. These results hold promise that morphometric analysis can be used to generate transMEM (middle ear mucosa) gas conductance estimates for MEM geometries representative of the shift from healthy to pathologic states (e.g. increased MEM thickness and capillary density). Objectives. Novel strategies to treat otitis media with effusion require a better understanding of how MEM geometry affects gas transport. Earlier studies developed techniques to empirically measure transMEM gas conductance and to estimate conductance using morphometric models of MEM geometry. We used chinchillas to determine the correspondence between experimentally measured transMEM CO[2] conductance and that predicted by morphometric study of the MEM. Materials and methods. TransMEM CO[2] conductance was measured unilaterally in 10 chinchillas; the animals were killed and the ME was removed and processed for morphometric analyses of MEM geometry. Results. The average measured and estimated transMEM CO[2] conductances were 4.87+/-2.30x10[-10] and 1.75+/-0.29x10[-10] mol/s/mmHg, respectively. The magnitude and direction of the estimate error were similar for all ears, suggesting a fixed, negative bias to the estimate. A theoretically consistent source for this bias was identified as the representation of the true diffusional length within a 3-D geometry using a 2-D modeling platform. Best estimate correction for this effect based on available data significantly reduced the estimate bias. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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