Interaction between gemcitabine and warfarin causing gastrointestinal bleeding in a patient with pancreatic cancer.
Gemcitabine (Gemzar) is the only chemotherapeutic agent approved by the U.S. Food and DrugAdministration (FDA) for the treatment of advanced pancreatic cancer. Thromboembolism requiring anticoagulation is a common paraneoplastic complication in these patients. We report a case of patient with pancre...
| Publicado en: | Journal of Applied Research Vol. 5; no. 3; pp. 434 - 438 |
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| Autor principal: | |
| Formato: | case study Journal Article |
| Publicado: |
Therapeutic Solutions LLC
2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106325534&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106325534 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1537064X I4L jtl: Journal of Applied Research issn: 1537064X maglogo: N pubinfo: dt: 2005 vid: 5 iid: 3 pid: 13467 pub: Therapeutic Solutions LLC place: Newtown, Pennsylvania artinfo: ui: 106325534 106325534 2009257695 106325534 ppf: 434 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Interaction between gemcitabine and warfarin causing gastrointestinal bleeding in a patient with pancreatic cancer. aug: au: Saif MW affil: Section of Medical Oncology, Yale University School of Medicine, New Haven, CT sug: subj: Antineoplastic Agents Adverse Effects Antineoplastic Agents Therapeutic Use Chemotherapy, Cancer Drug Interactions Pancreatic Neoplasms Drug Therapy Warfarin Adverse Effects Warfarin Therapeutic Use Aged Atrial Fibrillation Endoscopy Methods Gastrointestinal Diseases Etiology Hemorrhage Etiology Male Pancreatic Neoplasms Complications Pancreatic Neoplasms Radiography Thromboembolism Etiology Ulcer Etiology Aged: 65+ years Male ab: Gemcitabine (Gemzar) is the only chemotherapeutic agent approved by the U.S. Food and DrugAdministration (FDA) for the treatment of advanced pancreatic cancer. Thromboembolism requiring anticoagulation is a common paraneoplastic complication in these patients. We report a case of patient with pancreatic cancer, complicated by gastrointestinal bleeding following therapy with concomitant gemcitabine-warfarin (Coumadin).The patient was a 65-year-old male with medical history notable for atrial fibrillation for which he was taking warfarin 57.5 mg/week (international normalized ratio [INR] 1.94). He received capecitabine-radiotherapy for locally advanced pancreatic cancer. Later, he developed multiple liver metastases. The patient was started on gemcitabine. At the end of first cycle, he experienced bright red blood per rectum. His platelet count was normal, but his INR was noted to be significantly elevated at 8.00. Esophagogastroduodenoscopy (EGD) revealed 2 antral ulcers and a duodenal ulcer. The patient was stabilized and recovered without further incident.Patients with pancreatic cancer who receive warfarin and gemcitabine should be monitored for any potential drug interactions. Weekly prothrombin time (PT)/INRs for anticoagulated patients receiving gemcitabine is suggested. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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