Investigation of Helicobacter pylori infection in beta-thalassaemia major patients with recurrent abdominal pain.
Background: Recurrent abdominal pain (RAP) affects many children, especially those affected by beta-thalassaemia major. The role of Helicobacter pylori is still unclear in children with RAP.Objectives: The aim of the present study was the comparison of beta-thalassaemia major patients and normal con...
| Publicado en: | European Journal of Gastroenterology & Hepatology Vol. 17; no. 12; pp. 1363 - 1368 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Dec2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106347846&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106347846 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0954691X 8CE jtl: European Journal of Gastroenterology & Hepatology issn: 0954691X maglogo: N pubinfo: dt: Dec2005 vid: 17 iid: 12 pid: 5086 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 106347846 106347846 NLM16292091 2009291444 10.1097/00042737-200512000-00016 NLM16292091 106347846 ppf: 1363 ppct: 5 formats: tig: atl: Investigation of Helicobacter pylori infection in beta-thalassaemia major patients with recurrent abdominal pain. aug: au: Karimi M Imanieh MH Ghiam AF Hashemi Z Karimi, Mehran Hadi Imanieh, Mohammad Ghiam, Alireza Fotouhi Hashemi, Zahra affil: Haemostasis & Thrombosis Unit, Haematology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, Iran sug: subj: Abdominal Pain Etiology Helicobacter Infections Thalassemia Complications Academic Medical Centers Adolescence Adult Age Factors Chelation Therapy Chi Square Test Child Comparative Studies Data Analysis Software Descriptive Statistics Endoscopy Female Funding Source Helicobacter Infections Diagnosis Helicobacter Infections Drug Therapy Helicobacter Infections Physiopathology Helicobacter Infections Risk Factors Helicobacter Infections Symptoms Helicobacter Infections Transmission Helicobacter Pylori Iran Male Pearson's Correlation Coefficient Prospective Studies Random Sample Splenectomy T-Tests Thalassemia Epidemiology Thalassemia Physiopathology Thalassemia Therapy Human Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Female Male ab: Background: Recurrent abdominal pain (RAP) affects many children, especially those affected by beta-thalassaemia major. The role of Helicobacter pylori is still unclear in children with RAP.Objectives: The aim of the present study was the comparison of beta-thalassaemia major patients and normal controls with RAP in H. pylori infection. The factors influencing H. pylori prevalence were also investigated.Methods: A series of 50 beta-thalassaemia major cases (30 female, 20 male; aged 6-25 years) and 50 age-matched and sex-matched controls, both presenting with RAP, were recruited during a period of 18 months. The study participants were obtained through a multistage random sampling method among those that met Apley's criteria. All the patients and controls had undergone diagnostic oesophagogastroduodenoscopy with biopsy. H. pylori infection was confirmed by two histopathological examinations on an endoscopy sample and a rapid urease test.Results: H. pylori infection in thalassaemic patients was more common than in controls [34/50 (68%) versus 30/50 (60%)], but this higher frequency was not statistically significant. A clear relationship was found between the prevalence of H. pylori and age, duration of transfusion/chelation programmes, pain duration and splenectomy. In contrast, H. pylori did not correlate with abdominal pain characteristics, blood group, serum ferritin level and pathology of the upper gastrointestinal tract. The most frequent endoscopy abnormality was gastritis (72%). Nausea and heartburn were the leading associated symptoms.Conclusion: The high prevalence of H. pylori infection suggests that H. pylori should be remembered as a probable cause of RAP in beta-thalassaemia major patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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