Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women.
Background: Recent reports suggest that Helicobacter pylori infection can potentially increase the risk of colorectal cancer. The purpose of this study was to assess the association between H. pylori infection and the risk of colorectal adenoma and adenocarcinoma, and to evaluate any differences on...
| Publicado en: | Journal of Gastroenterology Vol. 40; no. 9; pp. 887 - 894 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106348243&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106348243 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09441174 EJ7 jtl: Journal of Gastroenterology issn: 09441174 maglogo: N pubinfo: dt: Sep2005 vid: 40 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 106348243 NLM16211345 2009292043 10.1007/s00535-005-1649-1 NLM16211345 106348243 ppf: 887 ppct: 7 formats: tig: atl: Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women. aug: au: Fujimori S Kishida T Kobayashi T Sekita Y Seo T Nagata K Tatsuguchi A Gudis K Yokoi K Tanaka N Yamashita K Tajiri T Ohaki Y Sakamoto C Fujimori, Shunji Kishida, Teruyuki Kobayashi, Tsuyoshi Sekita, Yoshihisa Seo, Tsuguhiko Nagata, Kazuhiro affil: Third Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan sug: subj: Adenocarcinoma Etiology Adenoma Etiology Colorectal Neoplasms Etiology Helicobacter Infections Complications Helicobacter Pylori Adenocarcinoma Epidemiology Adenocarcinoma Risk Factors Adenoma Epidemiology Adenoma Risk Factors Adult Aged Aged, 80 and Over Case Control Studies Colorectal Neoplasms Epidemiology Colorectal Neoplasms Risk Factors Data Analysis, Statistical Descriptive Statistics Epidemiological Research Female Japan Male Middle Age Prevalence Human Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Background: Recent reports suggest that Helicobacter pylori infection can potentially increase the risk of colorectal cancer. The purpose of this study was to assess the association between H. pylori infection and the risk of colorectal adenoma and adenocarcinoma, and to evaluate any differences on the basis of sex.Methods: The subjects were 669 (40- to 80-year-old) patients who underwent both barium enema examination and total colonoscopy, and who were evaluated for H. pylori infection by (13)C-urea breath test, urease test, or histological diagnosis of biopsied gastric specimens. There were 142 H. pylori-negative and 527-positive patients. The odds ratios (ORs) for H. pylori-positive patients with colorectal adenoma and adenocarcinoma, and for tumor patients with either adenoma or adenocarcinoma were calculated.Results: Among the H. pylori-negative patients, there were 52 patients without tumor, 63 with adenoma, 27 with adenocarcinoma, and 90 with tumor. Among the H. pylori-positive patients, there were 136, 264, 127, and 391 patients respectively. Pooling all subjects, those infected with H. pylori had a significantly increased OR for adenoma, adenocarcinoma, or tumor, compared to H. pylori-free patients (OR, 1.60, 1.80, and 1.66, respectively). For female H. pylori-positive subjects, the risk of having adenocarcinoma or tumor was significantly higher than that for their H. pylori-free counterparts, while for male H. pylori-positive and -negative subjects, there was no such significant difference.Conclusions: The results therefore suggest that, in patients aged 40-80 years, H. pylori infection increased the risk of colorectal adenoma and adenocarcinoma, with significantly higher risks for female patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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