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Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects.

AIMS: This study examined dose-response effects of oral cocaine on the inhibitory control of behavior in adult cocaine users using two different behavioral models of inhibitory control. DESIGN: Adults (n = 12) with a history of cocaine use performed the stop-signal and cue-dependent go-no-go task to...

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Publicado en:Addiction Vol. 101; no. 9; pp. 1323 - 1333
Autores principales: Fillmore MT, Rush CR, Hays L
Formato: research tables/charts Journal Article
Publicado: Wiley-Blackwell Sep2006
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Sep2006
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1111/j.1360-0443.2006.01522.x
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        atl: Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects.
      aug:
        au:
          Fillmore MT
          Rush CR
          Hays L
        affil: Department of Psychology, University of Kentucky, Lexington, KY. 40506-0044; fillmore@uky.edu
      sug:
        subj:
          Cocaine
          Dose-Response Relationship
          Reaction Time Drug Effects
          Analysis of Variance
          Cocaine Administration and Dosage
          Cues
          Experimental Studies
          Female
          Funding Source
          Kentucky
          Male
          Neuropsychological Tests
          Paired T-Tests
          Placebos
          Questionnaires
          Regression
          Self Report
          Persons with Substance Use Disorders
          Human
          Female
          Male
      ab: AIMS: This study examined dose-response effects of oral cocaine on the inhibitory control of behavior in adult cocaine users using two different behavioral models of inhibitory control. DESIGN: Adults (n = 12) with a history of cocaine use performed the stop-signal and cue-dependent go-no-go task to measure inhibitory control of behavior in response to a range of oral cocaine HCl doses (0, 100, 200 and 300 mg). FINDINGS: Although both tasks showed cocaine-induced facilitation of inhibitory control, dose-response functions differed depending on the measures. The stop-signal measure revealed a quadratic dose-response function and the cued go-no-go measure showed a more orderly, linear improvement as a function of dose. CONCLUSIONS: The evidence suggests a two-phasic dose-response in which facilitating effects of stimulant drugs on inhibitory control might be limited to a range of intermediate doses, above which improvement is no longer evident and impairing effects could possibly emerge.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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