Dietary supplement-related adverse events reported to the California Poison Control System.
PURPOSE: Dietary supplement (DS)-related adverse events (AEs) reported to the California Poison Control System (CPCS) were studied. METHODS: The CPCS database was used to search for all telephone calls from consumers concerning DS-related AEs received during the six-month period between April and Se...
| Publicado en: | American Journal of Health-System Pharmacy Vol. 62; no. 14; pp. 1476 - 1483 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
7/15/2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=106372965&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 106372965 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10792082 1X3 jtl: American Journal of Health-System Pharmacy issn: 10792082 maglogo: N pubinfo: dt: 7/15/2005 vid: 62 iid: 14 pid: 622 pub: Oxford University Press / USA artinfo: ui: 106372965 2009068490 10.2146/ajhp040412 NLM15998927 106372965 ppf: 1476 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Dietary supplement-related adverse events reported to the California Poison Control System. aug: au: Dennehy CE Tsourounis C Horn AJ affil: Associate Clinical Professor, School of Pharmacy, University of California San Francisco sug: subj: Dietary Supplements Poisoning Adolescence Adult California Child Child, Preschool Convenience Sample Descriptive Research Descriptive Statistics Dietary Supplements Classification Ephedra Infant Overdose Poison Control Centers Poisoning Classification Poisoning Symptoms Record Review Telephone Human Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Child, Preschool: 2-5 years Infant: 1-23 months ab: PURPOSE: Dietary supplement (DS)-related adverse events (AEs) reported to the California Poison Control System (CPCS) were studied. METHODS: The CPCS database was used to search for all telephone calls from consumers concerning DS-related AEs received during the six-month period between April and September 2002. The calls were characterized according to the substance involved, the caller's age (adult or pediatric), and the type of ingestion (accidental or intentional). Each exposure in which symptoms were reported was categorized as involving an AE. Each AE was assessed for severity and causality. RESULTS: Data on a total of 1183 telephone calls were retrieved, of which 828 calls (70%) met the study's inclusion criteria. DS exposure occurred in 389 adults (47%) and 438 children (53%). DS ingestion was accidental in 360 patients (43%) and intentional in 467 patients (56%). Exposure resulted in an AE in 480 patients (58%). AEs were reported in 353 patients (74%) who ingested products containing ephedra; other exposures frequently involved zinc, kava, creatine, and valerian. AEs were classified as moderate in 198 patients (41%) who ingested a DS and as severe in 40 patients (8%). One patient had a fatal reaction. Among the 480 AEs in DS-exposed consumers, the DS was classified as the definite cause of 1 AE (<1%) and a probable cause of 237 (49.4%). The most frequently reported AE symptoms were increased heart rate (45%), agitation (30%), vomiting (30%), and nausea (15%). CONCLUSION: A majority of DS-related AEs reported by consumers to CPCS involved ephedra-containing products. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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